<p>The resonance of neuronal discharge is a critical physiological mechanism in the nervous system, playing a vital role in information processing and the generation of rhythmic activities. In this study, we investigate the effects of synaptic and autaptic delays on firing resonance in a two-coupled neuron motif model. Through numerical simulations, we demonstrate that both synaptic and autaptic delays can induce multiple firing resonance phenomena, with their interaction leading to the formation of distinct resonance regions, as well as either in-phase or antiphase synchronization firing pattern. Specifically, we observe that increasing the strength of synapses or autapses modulates the resonance behavior, with synaptic delays inducing resonance peaks at shorter intervals compared to autaptic delays. We also provided a qualitative explanation for the observed resonance by combining the loop formed by synapses and autapses, neuronal refractory period, and the interaction of synaptic currents. These findings provide insights into how delays in neural signal transmission influence neuronal activity and resonance. Our study underscores the importance of considering both synaptic and autaptic delays in neural dynamics research and lays the groundwork for further exploration of delay effects in complex neural networks.</p>