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<p>Piper kadsura (Choisy) Ohwi, a traditional medicinal plant used in East Asia, is renowned for its anti-inflammatory and antioxidant properties. Its bioactive components, such as Hancinone and Futoquinol, show potential in treating neurodegenerative disorders like Alzheimer’s disease (AD). Aim of the study: This study investigates the neuroprotective effects of Piper kadsura extract (PK) and its active components, Hancinone (C1) and Futoquinol (C2), in Aβ<sub>25−35</sub>-induced AD models. PK, C1, and C2 were evaluated in Aβ<sub>25−35</sub>-induced PC-12 and N9 cells, as well as a mouse model of AD. Cellular assays, Seahorse analysis, and molecular docking were used to explore glycolysis, oxidative stress, and apoptosis. Gut microbiota composition was analyzed via 16&#xa0;S rDNA sequencing. PK, C1, and C2 significantly improved cell viability, restored glycolysis, and reduced oxidative stress by activating the SIRT1/PPARγ/GLUT1 pathway. PK also alleviated neuronal damage and enhanced cognitive performance in mice. Gut microbiota analysis revealed increased beneficial bacteria (e.g., Lactobacillus) and enriched glycolysis-related pathways. Piper kadsura and its components exhibit multifaceted neuroprotective effects by modulating energy metabolism, reducing oxidative stress, and regulating the gut-brain axis. These findings support the therapeutic potential of Piper kadsura in AD treatment.</p>

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Piper Kadsura Extract and its Bioactive Components Attenuates Aβ25−35-Induced Neurotoxicity by Modulating Glycolysis and Activating the SIRT1/PPARγ/GLUT1 Axis

  • 期刊论文

  • 发表日期：

    2025年6月27日

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  • Kaili Ye,
  • Mengnan Zeng,
  • Beibei Zhang,
  • Fengxiao Hao,
  • Pengli Guo,
  • Yuhan Zhang,
  • Tong Liu,
  • Hui Chen,
  • Weisheng Feng,
  • Xiaoke Zheng

摘要

Piper kadsura (Choisy) Ohwi, a traditional medicinal plant used in East Asia, is renowned for its anti-inflammatory and antioxidant properties. Its bioactive components, such as Hancinone and Futoquinol, show potential in treating neurodegenerative disorders like Alzheimer’s disease (AD). Aim of the study: This study investigates the neuroprotective effects of Piper kadsura extract (PK) and its active components, Hancinone (C1) and Futoquinol (C2), in Aβ25−35-induced AD models. PK, C1, and C2 were evaluated in Aβ25−35-induced PC-12 and N9 cells, as well as a mouse model of AD. Cellular assays, Seahorse analysis, and molecular docking were used to explore glycolysis, oxidative stress, and apoptosis. Gut microbiota composition was analyzed via 16 S rDNA sequencing. PK, C1, and C2 significantly improved cell viability, restored glycolysis, and reduced oxidative stress by activating the SIRT1/PPARγ/GLUT1 pathway. PK also alleviated neuronal damage and enhanced cognitive performance in mice. Gut microbiota analysis revealed increased beneficial bacteria (e.g., Lactobacillus) and enriched glycolysis-related pathways. Piper kadsura and its components exhibit multifaceted neuroprotective effects by modulating energy metabolism, reducing oxidative stress, and regulating the gut-brain axis. These findings support the therapeutic potential of Piper kadsura in AD treatment.