<p>The characteristics of the lesion areas in medical images are complex, and existing fully connected layer-based neural networks still cannot address the issue of linear kernels, making them inadequate for handling the nonlinear classification problem of medical image data. This paper investigates a multi-scale feature joint prediction Kolmogorov-Arnold Network convolutional network combined with a spatial attention mechanism for medical image classification applications. In this article, we propose the Multi-Scale Feature prediction network combined with Kolmogorov-Arnold Network. In this model, convolutional blocks are concatenated to output feature maps of different scales. These feature maps are then passed through a spatial attention module, and the output is weighted and summed using learnable weights in the Kolmogorov-Arnold Network layer for classification. The model is trained, tuned, and tested on three publicly available medical image datasets, including the skin cancer image dataset, COVID-19 lung CT dataset, and brain tumor MRI dataset. Experimental results show that the proposed model demonstrates strong performance in classification tasks across four datasets, achieving an accuracy of 87.27% for binary skin cancer classification, 94.12% for the three-class COVID-19 CT classification, and 97.48% for the four-class brain tumor CT classification. This performance outperforms the classification accuracy of the selected comparison methods. Additionally, we applied a perturbation rate of 0.5% and 1.0% using the FGSM method on the test sets of the three datasets and re-tested, finding that our method achieved higher accuracy than the comparison methods. Comprehensive experimental results validate the effectiveness of our proposed method, demonstrating its applicability and robustness in different medical scenarios. This approach is expected to enhance the performance of medical image-assisted classification.</p>