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<p>Neurodegenerative diseases are a&#xa0;global burden that can be fatal, caused by various reasons, including genetic and environmental factors, oxidative stress, aging, disrupted protein folding metabolism, neuroinflammation, and other physical complications. A&#xa0;glial cell, an important part of the brain, is responsible for the stability and functional integrity of neural networks. Recent research has investigated both the positive and negative impacts of glial cells in neurodegenerative diseases, as they have both neuroprotective effects and may also contribute to the neurodegeneration process, especially in the context of neurodegenerative diseases. This study discussed the general pathophysiology and the pathophysiological impact of glial cells in multiple neurodegenerative diseases. We further discussed the impact and mechanisms of glial cells on the development and neuroprotection in various types of neurodegenerative diseases.</p>

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Glial cells in neurodegenerative diseases: a review

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • Alif Hasan Pranto,
  • Shahad Saif Khandker,
  • Md Ekhtiar Uddin,
  • Shamima Aktar,
  • Sumaiya Islam Mumu,
  • Rafiul Islam Khan,
  • Nourin Khan Chowdhury,
  • Jarukun Prekbunjun,
  • Asifuzzaman Zisan,
  • Rahima Begum

摘要

Neurodegenerative diseases are a global burden that can be fatal, caused by various reasons, including genetic and environmental factors, oxidative stress, aging, disrupted protein folding metabolism, neuroinflammation, and other physical complications. A glial cell, an important part of the brain, is responsible for the stability and functional integrity of neural networks. Recent research has investigated both the positive and negative impacts of glial cells in neurodegenerative diseases, as they have both neuroprotective effects and may also contribute to the neurodegeneration process, especially in the context of neurodegenerative diseases. This study discussed the general pathophysiology and the pathophysiological impact of glial cells in multiple neurodegenerative diseases. We further discussed the impact and mechanisms of glial cells on the development and neuroprotection in various types of neurodegenerative diseases.