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Objective <p>To investigate the clinical relevance of upper limb somatosensory evoked potential (SEP) status in assessing concurrent and short-term predictive relationships with functional outcomes in patients with subacute stroke.</p> Design <p>Retrospective observational study using mixed-effects modeling.</p> Setting <p>Inpatient rehabilitation unit at a&#xa0;university-affiliated tertiary hospital.</p> Participants <p>A&#xa0;total of 111 patients with subacute stroke who underwent upper limb SEP testing and completed functional assessments at admission and discharge.</p> Main measures <p>Upper limb SEP responses were categorized as non-responsive, abnormal, or normal. Functional outcomes included the Fugl-Meyer assessment for upper limb (FMA-U/L), box and block test (BBT), Functional Independence Measure (FIM), and Korean modified Barthel index (K-MBI). Mixed-effects models were used to examine both cross-sectional associations at admission and longitudinal changes over time, adjusting for age, sex, and cognitive function (K-MMSE).</p> Results <p>Patients with abnormal or normal SEP responses had significantly higher FMA-U/L, FIM, and K‑MBI scores at admission compared to those with non-responsive SEP, indicating concurrent associations between SEP integrity and functional capacity. In longitudinal analysis, these groups also showed significantly greater improvement, with the largest effect sizes observed for ADL outcomes. SEP normal status consistently showed the strongest associations across all functional domains. Cognitive function was a&#xa0;significant predictor in most models, while sex and age showed variable effects.</p> Conclusions <p>Upper limb SEP status at admission is a&#xa0;significant marker of both baseline functional status and short-term recovery potential in patients with subacute stroke. SEP evaluation may provide clinically meaningful insights for understanding sensory pathway integrity and for short-term prognosis and to support neurophysiologically informed rehabilitation planning.</p>

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Predictive value of upper limb somatosensory evoked potentials for functional and activities of daily living recovery in subacute stroke

  • 期刊论文

  • 发表日期：

    2026年6月19日

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  • Jungwoo Shim

摘要

Objective

To investigate the clinical relevance of upper limb somatosensory evoked potential (SEP) status in assessing concurrent and short-term predictive relationships with functional outcomes in patients with subacute stroke.

Design

Retrospective observational study using mixed-effects modeling.

Setting

Inpatient rehabilitation unit at a university-affiliated tertiary hospital.

Participants

A total of 111 patients with subacute stroke who underwent upper limb SEP testing and completed functional assessments at admission and discharge.

Main measures

Upper limb SEP responses were categorized as non-responsive, abnormal, or normal. Functional outcomes included the Fugl-Meyer assessment for upper limb (FMA-U/L), box and block test (BBT), Functional Independence Measure (FIM), and Korean modified Barthel index (K-MBI). Mixed-effects models were used to examine both cross-sectional associations at admission and longitudinal changes over time, adjusting for age, sex, and cognitive function (K-MMSE).

Results

Patients with abnormal or normal SEP responses had significantly higher FMA-U/L, FIM, and K‑MBI scores at admission compared to those with non-responsive SEP, indicating concurrent associations between SEP integrity and functional capacity. In longitudinal analysis, these groups also showed significantly greater improvement, with the largest effect sizes observed for ADL outcomes. SEP normal status consistently showed the strongest associations across all functional domains. Cognitive function was a significant predictor in most models, while sex and age showed variable effects.

Conclusions

Upper limb SEP status at admission is a significant marker of both baseline functional status and short-term recovery potential in patients with subacute stroke. SEP evaluation may provide clinically meaningful insights for understanding sensory pathway integrity and for short-term prognosis and to support neurophysiologically informed rehabilitation planning.