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Objective <p>Acute cerebral infarction (ACI) is the most common type of stroke, and most patients are left with sequelae such as hemiparesis and crooked mouth after treatment. Therefore, this study investigated the diagnostic and prognostic role of miR-1271-5p in ACI patients and its potential regulatory mechanisms.</p> Methods <p>134 patients with ACI and 130 controls were included. The expression of miR-1271-5p as well as mRNA in serum was examined by RT-qPCR. The binding relationship between miR-1271-5p and IGF1R was verified by DLR. ROC curves analyzed the role of miR-1271-5p in the diagnosis of ACI patients.</p> Results <p>MiR-1271-5p was significantly elevated in ACI patients. The AUC of the ROC curve for miR-1271-5p in diagnosing ACI was 0.921. miR-1271-5p was up-regulated in ACI patients with poor prognosis, and it is expected to be a&#xa0;diagnostic and prognostic marker for ACI. miR-1271-5p downstream target genes were mainly enriched in the MAPK signaling pathway, and among the nodes associated with it, the IGF1R level was decreased in ACI patients.</p> Conclusion <p>miR-1271-5p is expected to be a&#xa0;diagnostic and prognostic marker for ACI due to its high expression in ACI patients and patients with poor prognosis. Mechanistically, miR-1271-5p might influence ACI occurrence and patient prognosis by affecting IGF1R.</p>

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Clinical significance of miR-1271-5p in serum level for acute cerebral infarction and bioinformatics analysis for its target genes

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Yinzhen Liu,
  • Min Yang,
  • Liang He

摘要

Objective

Acute cerebral infarction (ACI) is the most common type of stroke, and most patients are left with sequelae such as hemiparesis and crooked mouth after treatment. Therefore, this study investigated the diagnostic and prognostic role of miR-1271-5p in ACI patients and its potential regulatory mechanisms.

Methods

134 patients with ACI and 130 controls were included. The expression of miR-1271-5p as well as mRNA in serum was examined by RT-qPCR. The binding relationship between miR-1271-5p and IGF1R was verified by DLR. ROC curves analyzed the role of miR-1271-5p in the diagnosis of ACI patients.

Results

MiR-1271-5p was significantly elevated in ACI patients. The AUC of the ROC curve for miR-1271-5p in diagnosing ACI was 0.921. miR-1271-5p was up-regulated in ACI patients with poor prognosis, and it is expected to be a diagnostic and prognostic marker for ACI. miR-1271-5p downstream target genes were mainly enriched in the MAPK signaling pathway, and among the nodes associated with it, the IGF1R level was decreased in ACI patients.

Conclusion

miR-1271-5p is expected to be a diagnostic and prognostic marker for ACI due to its high expression in ACI patients and patients with poor prognosis. Mechanistically, miR-1271-5p might influence ACI occurrence and patient prognosis by affecting IGF1R.