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<p>Agomelatine is a&#xa0;melatonergic antidepressant that has been shown to exert beneficial effects on stress-related behavioral and neurobiological outcomes. The present study investigated its impact on cognitive functions and neurogenesis in rats given acute stress. Male and female rats (<i>n</i> = 10 per group) were divided into four subgroups: control, acute stress, agomelatine-treated control, and agomelatine-treated stress. Agomelatine (10 mg/kg/day) was supplied via gavage for 14&#xa0;days. Behavioral assays (sucrose preference, forced swimming test, Y‑maze) and immunohistochemical analyses (DCX, Nestin, Ki-67) were conducted. Agomelatine treatment improved cognitive function in stressed rats, reduced cortisol levels, and increased markers of hippocampal neurogenesis. These data demonstrate that agomelatine mitigates acute stress-induced behavioral and neuroendocrine changes, suggesting its potential function in stress-related disease.</p>

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The effects of agomelatine on cognitive functions and neurogenesis in male and female rats subjected to acute stress

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Umut Bakkaloğlu,
  • Burak Tan,
  • Kamile Özdıraz,
  • Betül Yalçın,
  • Arzu Hanım Yay,
  • Ercan Babur,
  • Asuman Gölgeli

摘要

Agomelatine is a melatonergic antidepressant that has been shown to exert beneficial effects on stress-related behavioral and neurobiological outcomes. The present study investigated its impact on cognitive functions and neurogenesis in rats given acute stress. Male and female rats (n = 10 per group) were divided into four subgroups: control, acute stress, agomelatine-treated control, and agomelatine-treated stress. Agomelatine (10 mg/kg/day) was supplied via gavage for 14 days. Behavioral assays (sucrose preference, forced swimming test, Y‑maze) and immunohistochemical analyses (DCX, Nestin, Ki-67) were conducted. Agomelatine treatment improved cognitive function in stressed rats, reduced cortisol levels, and increased markers of hippocampal neurogenesis. These data demonstrate that agomelatine mitigates acute stress-induced behavioral and neuroendocrine changes, suggesting its potential function in stress-related disease.