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Objective <p>The management of sporadic vestibular schwannoma (VS) with stereotactic radiosurgery (SRS) is becoming increasingly common worldwide. Despite its efficacy, treatment failure can occur in a subset of patients. This study aimed to describe the clinical outcomes of salvage microsurgery following failed primary SRS in patients with sporadic VS.</p> Methods <p>This retrospective study included adult patients (≥ 18 years) who underwent salvage microsurgery following failed primary SRS at six European tertiary referral centers. Data collection was performed from January 2012 to December 2022, and data analysis was performed from July to September 2025.</p> Results <p>Among 28 patients (15 men, 13 women), surgery indication was radiological regrowth in 27/28 patients. The median interval from SRS to salvage microsurgery was 48 months (range, 24–120), and the median age at time of salvage microsurgery was 53 years (range, 30–74). Axial diameter increased from median 18.5&#xa0;mm (range, 7.5–27) before SRS to 25&#xa0;mm (range, 10.5–33) before surgery. Gross total resection was achieved in 13/28 (46.4%). Complications occurred in 3/28 patients (10.7%). Serviceable hearing (AAO-HNS class A/B) declined from 10/20 patients (50.0%) pre-SRS to 4/24 (16.7%) preoperatively; all patients with postoperative follow-up (14/28) were AAO-HNS class D. Preoperative facial nerve function was House–Brackmann (HB) grade I in 25/28 patients (89.3%); good facial function (HB I–II) was seen in 14/27 (51.9%) at discharge and 11/15 (73.3%) at 12 months, with 3/15 (20.0%) remaining HB grade V–VI.</p> Conclusion <p>Salvage microsurgery is a viable therapeutic option for managing VS after failed SRS. GTR or NTR with a relatively low complication profile is achievable, although hearing preservation is not a realistic goal in this setting, whereas facial nerve function may improve postoperatively.</p>

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Salvage microsurgery for vestibular schwannoma after failed stereotactic radiosurgery: a multi-institutional retrospective study

  • 期刊论文

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  • 发表日期：

    2026年5月20日

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  • Filippo Friso,
  • Noa Ben Dor,
  • Alfredo Conti,
  • Alfredo Decio Fabbri,
  • Federico Calvaruso,
  • Virginia Dallari,
  • Francesca De Cecco,
  • Franco Federico Bochicchio,
  • Emanuele La Corte,
  • Tomasz Wojciechowski,
  • Kazimierz Niemczyk,
  • Adrian Drożdż,
  • Grzegorz Turek,
  • Lukas Anschuetz,
  • Davide Soloperto,
  • Giacomo Pavesi,
  • Barbara Masotto,
  • Daniele Marchioni,
  • Carmelo Sturiale,
  • Paolo Ferroli,
  • Francesco DiMeco,
  • Livio Presutti,
  • Giulia Molinari

摘要

Objective

The management of sporadic vestibular schwannoma (VS) with stereotactic radiosurgery (SRS) is becoming increasingly common worldwide. Despite its efficacy, treatment failure can occur in a subset of patients. This study aimed to describe the clinical outcomes of salvage microsurgery following failed primary SRS in patients with sporadic VS.

Methods

This retrospective study included adult patients (≥ 18 years) who underwent salvage microsurgery following failed primary SRS at six European tertiary referral centers. Data collection was performed from January 2012 to December 2022, and data analysis was performed from July to September 2025.

Results

Among 28 patients (15 men, 13 women), surgery indication was radiological regrowth in 27/28 patients. The median interval from SRS to salvage microsurgery was 48 months (range, 24–120), and the median age at time of salvage microsurgery was 53 years (range, 30–74). Axial diameter increased from median 18.5 mm (range, 7.5–27) before SRS to 25 mm (range, 10.5–33) before surgery. Gross total resection was achieved in 13/28 (46.4%). Complications occurred in 3/28 patients (10.7%). Serviceable hearing (AAO-HNS class A/B) declined from 10/20 patients (50.0%) pre-SRS to 4/24 (16.7%) preoperatively; all patients with postoperative follow-up (14/28) were AAO-HNS class D. Preoperative facial nerve function was House–Brackmann (HB) grade I in 25/28 patients (89.3%); good facial function (HB I–II) was seen in 14/27 (51.9%) at discharge and 11/15 (73.3%) at 12 months, with 3/15 (20.0%) remaining HB grade V–VI.

Conclusion

Salvage microsurgery is a viable therapeutic option for managing VS after failed SRS. GTR or NTR with a relatively low complication profile is achievable, although hearing preservation is not a realistic goal in this setting, whereas facial nerve function may improve postoperatively.