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Background <p>Peritumoral brain edema (PTBE) is a frequent finding in meningiomas and can significantly affect perioperative outcomes. In addition to well-established clinical, radiological, and histopathological risk factors, molecular markers such as Forkhead Box C1 (FOXC1) may also play a crucial role in the development of PTBE.</p> Methods <p>We conducted a retrospective, single-center study including 86 patients with histopathologically confirmed meningiomas. Preoperative MRI datasets were analyzed for tumor characteristics using 3D Slicer and ImageJ. FOXC1 expression was assessed immunohistochemically and dichotomized based on receiver operating characteristic (ROC) curve analysis. Univariate analyses were performed to evaluate associations between clinical, radiological, and histopathological variables and the presence of PTBE.</p> Results <p>PTBE was significantly associated with low FOXC1 expression (<i>p</i> = 0.015). Furthermore, WHO grade 2/3 meningiomas (<i>p</i> = 0.012), perioperative seizures (<i>p</i> = 0.024), subtype (<i>p</i> = 0.016), tumor laterality (<i>p</i> = 0.04), higher MIB-1 index <i>(p</i> &lt; 0.001) and tumor volume (<i>p</i> = 0.01) were also significantly associated with PTBE. Tumor localization (skull base vs. non-skull-base) and sex showed no significant correlation.</p> Conclusion <p>Combining molecular and radiological parameters could improve neurosurgical planning and perioperative management. Further studies are needed regarding the assessment of the response to anti-edematous therapies in low and high FOXC1 expressing meningiomas.</p>

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FOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月3日

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  • Alim Emre Basaran,
  • Max Braune,
  • Alonso Barrantes-Freer,
  • Wolf C. Mueller,
  • Martin Vychopen,
  • Erdem Güresir,
  • Johannes Wach

摘要

Background

Peritumoral brain edema (PTBE) is a frequent finding in meningiomas and can significantly affect perioperative outcomes. In addition to well-established clinical, radiological, and histopathological risk factors, molecular markers such as Forkhead Box C1 (FOXC1) may also play a crucial role in the development of PTBE.

Methods

We conducted a retrospective, single-center study including 86 patients with histopathologically confirmed meningiomas. Preoperative MRI datasets were analyzed for tumor characteristics using 3D Slicer and ImageJ. FOXC1 expression was assessed immunohistochemically and dichotomized based on receiver operating characteristic (ROC) curve analysis. Univariate analyses were performed to evaluate associations between clinical, radiological, and histopathological variables and the presence of PTBE.

Results

PTBE was significantly associated with low FOXC1 expression (p = 0.015). Furthermore, WHO grade 2/3 meningiomas (p = 0.012), perioperative seizures (p = 0.024), subtype (p = 0.016), tumor laterality (p = 0.04), higher MIB-1 index (p < 0.001) and tumor volume (p = 0.01) were also significantly associated with PTBE. Tumor localization (skull base vs. non-skull-base) and sex showed no significant correlation.

Conclusion

Combining molecular and radiological parameters could improve neurosurgical planning and perioperative management. Further studies are needed regarding the assessment of the response to anti-edematous therapies in low and high FOXC1 expressing meningiomas.