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Purpose <p>Circulating inflammatory indices derived from routine blood counts may offer pragmatic prognostic information in glioblastoma (GB), yet the prognostic role of plateletcrit (PCT) and of peri-treatment dynamics in leukocyte–platelet coupling remains underexplored.</p> Methods <p>We retrospectively studied 95 adults with histologically confirmed GB (48 men, 47 women; median age 64.5 years) treated adjuvantly with radiotherapy and chemotherapy with complete blood counts obtained at four windows: pre-operative, post-operative, pre-adjuvant, and post-adjuvant. From leukocytes, platelets (PLT), plateletcrit (PCT), and mean platelet volume (MPV) we derived all within-timepoint ratios and inter-timepoint differences (Δ). Overall survival (OS) in days was modeled using Cox proportional hazards (per + 1 SD), with Benjamini–Hochberg false-discovery summaries; a multivariable model adjusted for age, sex, extent of resection, radiotherapy, concomitant temozolomide (TMZ), and number of adjuvant TMZ cycles was calculated.</p> Results <p>Median overall survival (OS) was 406 days, with 80 deaths. In univariate models, dynamic indices predominated: the post-operative rise in leukocytes relative to plateletcrit (Δ post-op − pre-op leu/PCT) showed the strongest adverse association (HR 1.60, 95% CI 1.22–2.10; <i>p</i> = 0.0007; BH–FDR q = 0.09), with concordant signals for Δ leu/PLT (HR 1.43, 95% CI 1.14–1.79; <i>p</i> = 0.002) and a protective inverse for Δ PCT/leu (HR 0.66, 95% CI 0.50–0.87; <i>p</i> = 0.003). Cross-sectionally, higher post-operative leu/PCT and leu/PLT and higher post-adjuvant leukocytes and leu/MPV were adverse (all <i>p</i> &lt; 0.05). In the multivariable model adjusting for age, sex, extent of resection, radiotherapy, concomitant temozolomide (TMZ), and number of adjuvant TMZ cycles, Δ leu/PCT remained independently associated with worse OS (HR 1.62, 95% CI 1.04–2.52; <i>p</i> = 0.031), while concomitant TMZ (HR 0.18, 95% CI 0.05–0.68; <i>p</i> = 0.012) and greater adjuvant TMZ exposure (per + 1 SD; HR 0.48, 95% CI 0.29–0.78; <i>p</i> = 0.003) were protective.</p> Conclusions <p>Dynamic leukocyte–platelet coupling—especially Δ (post-op − pre-op) leu/PCT—provides independent prognostic information beyond standard covariates. CBC-based trajectories are low-cost and scalable and warrant prospective validation. Interpretation is limited by the absence of systematic MGMT methylation data and requires external validation and comparison with other prognostic scoring systems.</p>

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Perioperative leukocyte–plateletcrit shift as a prognostic signature in glioblastoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月20日

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  • Petr Krupa,
  • Filip Kotek,
  • Marketa Krupova,
  • Simona Paulikova,
  • Petra Kasparova,
  • Tomas Cesak

摘要

Purpose

Circulating inflammatory indices derived from routine blood counts may offer pragmatic prognostic information in glioblastoma (GB), yet the prognostic role of plateletcrit (PCT) and of peri-treatment dynamics in leukocyte–platelet coupling remains underexplored.

Methods

We retrospectively studied 95 adults with histologically confirmed GB (48 men, 47 women; median age 64.5 years) treated adjuvantly with radiotherapy and chemotherapy with complete blood counts obtained at four windows: pre-operative, post-operative, pre-adjuvant, and post-adjuvant. From leukocytes, platelets (PLT), plateletcrit (PCT), and mean platelet volume (MPV) we derived all within-timepoint ratios and inter-timepoint differences (Δ). Overall survival (OS) in days was modeled using Cox proportional hazards (per + 1 SD), with Benjamini–Hochberg false-discovery summaries; a multivariable model adjusted for age, sex, extent of resection, radiotherapy, concomitant temozolomide (TMZ), and number of adjuvant TMZ cycles was calculated.

Results

Median overall survival (OS) was 406 days, with 80 deaths. In univariate models, dynamic indices predominated: the post-operative rise in leukocytes relative to plateletcrit (Δ post-op − pre-op leu/PCT) showed the strongest adverse association (HR 1.60, 95% CI 1.22–2.10; p = 0.0007; BH–FDR q = 0.09), with concordant signals for Δ leu/PLT (HR 1.43, 95% CI 1.14–1.79; p = 0.002) and a protective inverse for Δ PCT/leu (HR 0.66, 95% CI 0.50–0.87; p = 0.003). Cross-sectionally, higher post-operative leu/PCT and leu/PLT and higher post-adjuvant leukocytes and leu/MPV were adverse (all p < 0.05). In the multivariable model adjusting for age, sex, extent of resection, radiotherapy, concomitant temozolomide (TMZ), and number of adjuvant TMZ cycles, Δ leu/PCT remained independently associated with worse OS (HR 1.62, 95% CI 1.04–2.52; p = 0.031), while concomitant TMZ (HR 0.18, 95% CI 0.05–0.68; p = 0.012) and greater adjuvant TMZ exposure (per + 1 SD; HR 0.48, 95% CI 0.29–0.78; p = 0.003) were protective.

Conclusions

Dynamic leukocyte–platelet coupling—especially Δ (post-op − pre-op) leu/PCT—provides independent prognostic information beyond standard covariates. CBC-based trajectories are low-cost and scalable and warrant prospective validation. Interpretation is limited by the absence of systematic MGMT methylation data and requires external validation and comparison with other prognostic scoring systems.