Scholarlink

Purpose <p>This study evaluated prognostic factors and longitudinal outcomes associated with gamma knife radiosurgery (GKRS) in treating brain metastases from breast cancer, and assessed the efficacy of repeated GKRS in prolonging intracranial disease control.</p> Methods <p>In this retrospective study, we reviewed 159 breast cancer patients involving 640 brain metastases who underwent GKRS at a tertiary medical center. Overall survival (OS), local control (LC), and distant intracranial control were estimated using the Kaplan-Meier method. Prognostic factors were estimated using Cox regression models. The effect of repeat GKRS on intracranial disease control was also examined.</p> Results <p>The median OS was 19.2 months. In multivariate analysis, the Karnofsky Performance Scale (KPS), HER2 positivity, and ER/PR positivity were independently associated with longer survival. LC rates were 88.9% at 6 months and 83.0% at 12 months. Factors significantly associated with improved LC included a higher margin dose, HER2-negative status, smaller tumor volume, and absence of prior whole-brain radiotherapy (WBRT). Distant intracranial failure within 12 month occurred in 57.0% of patients. Median intracranial control among the 44 patients who underwent repeated GKRS (28.1 months) was significantly longer than those who received single GKRS (8.0 months; <i>p</i> &lt; 0.001).</p> Conclusion <p>GKRS provides effective local tumor control and favorable survival outcomes for patients with breast cancer brain metastases. KPS score and receptor status (ER/PR and HER2) are significant predictors of overall survival. Repeat GKRS is a promising strategy for prolonging intracranial control and may reduce the need for WBRT or surgical intervention in selected patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Gamma knife radiosurgery for breast cancer brain metastasis: survival outcomes, prognotic factors, and the role of repeat treatment

  • 期刊论文

  • 发表日期：

    2025年8月21日

查看全文
  • Ching-Ying Wang,
  • Chun-Fu Lin,
  • Huai-Che Yang,
  • Chun-Yu Liu,
  • Jiun-I Lai,
  • Hsiu-Mei Wu,
  • Wen-Yuh Chung,
  • Cheng-Ying Shiau,
  • Wan-Yuo Guo,
  • Cheng-Chia Lee

摘要

Purpose

This study evaluated prognostic factors and longitudinal outcomes associated with gamma knife radiosurgery (GKRS) in treating brain metastases from breast cancer, and assessed the efficacy of repeated GKRS in prolonging intracranial disease control.

Methods

In this retrospective study, we reviewed 159 breast cancer patients involving 640 brain metastases who underwent GKRS at a tertiary medical center. Overall survival (OS), local control (LC), and distant intracranial control were estimated using the Kaplan-Meier method. Prognostic factors were estimated using Cox regression models. The effect of repeat GKRS on intracranial disease control was also examined.

Results

The median OS was 19.2 months. In multivariate analysis, the Karnofsky Performance Scale (KPS), HER2 positivity, and ER/PR positivity were independently associated with longer survival. LC rates were 88.9% at 6 months and 83.0% at 12 months. Factors significantly associated with improved LC included a higher margin dose, HER2-negative status, smaller tumor volume, and absence of prior whole-brain radiotherapy (WBRT). Distant intracranial failure within 12 month occurred in 57.0% of patients. Median intracranial control among the 44 patients who underwent repeated GKRS (28.1 months) was significantly longer than those who received single GKRS (8.0 months; p < 0.001).

Conclusion

GKRS provides effective local tumor control and favorable survival outcomes for patients with breast cancer brain metastases. KPS score and receptor status (ER/PR and HER2) are significant predictors of overall survival. Repeat GKRS is a promising strategy for prolonging intracranial control and may reduce the need for WBRT or surgical intervention in selected patients.