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Purpose <p>While clinical outcomes of glioblastoma (GBM) are well-documented, its socio-economic impact, particularly on return to work (RTW) remains unexplored. In this study we aimed to identify the predictors of RTW at 6 months postoperatively in patients undergoing GBM treatment and to assess its association with post-operative neurological deficits and median overall survival (mOS).</p> Methods <p>We retrospectively studied 106 adults with pre-operative employment, undergoing primary GBM resection or biopsy at three tertiary centers. RTW at 3 and 6 months postoperatively were assessed using univariate and multivariate analyses.</p> Results <p>After 6 months 33 patients (33.1%) were able to RTW. Factors associated with lower odds of RTW included female sex (<i>p</i> = 0.039), Karnofsky Performance Scale (KPS) &lt; 80 at 2 weeks (<i>p</i> = 0.034), and 3 months post-operatively (<i>p</i> = 0.0001), right handedness (<i>p</i> = 0.038), and subtotal resection (<i>p</i> = 0.042). On multivariate analysis female sex (OR 0.238, 95% CI 0.077–0.733, <i>p</i> = 0.012) and three-month postoperative KPS &lt; 80 (OR 0.019, 95% CI 0.001–0.0293, <i>p</i> = 0.004) were the least likely to RTW at six months. Acute postoperative motor (<i>p</i> = 0.047), gait (<i>p</i> = 0.008) and cognitive deficits (<i>p</i> = 0.048) and persistent motor (<i>p</i> = 0.017), gait (<i>p</i> = 0.033) and language (<i>p</i> = 0.026) deficits were all associated with lesser RTW. Patients who returned to work had significantly longer mOS (21.44, <i>p</i> &lt; 0.001).</p> Conclusions <p>RTW at 6 months post GBM Surgery corelates with improved mOS. Female sex and lower post-operative KPS scores were the strongest predictors of reduced RTW.</p>

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Predictors of return to work following surgery in patients with glioblastoma: a retrospective multicenter study

  • 期刊论文

  • 发表日期：

    2025年5月13日

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  • Harshvardhan G. Iyer,
  • Ogechukwu K. Ariwodo,
  • Chase Mckevitt,
  • Paola Suarez Meade,
  • Lina Marenco-Hillembrand,
  • Andrea Otamendi-Lopez,
  • Leonardo José Monteiro de Macêdo Filho,
  • Steven S. Rosenfeld,
  • Christine Cordova,
  • Jennifer L. Peterson,
  • Daniel M. Trifiletti,
  • David S. Sabsevitz,
  • Ian F. Parney,
  • Terry C. Burns,
  • Fredric B. Meyer,
  • Bernard R. Bendok,
  • Krishna Chandan,
  • Rich Byrne,
  • Victoria Clark,
  • Alfredo Quinones-Hinojosa,
  • Wendy J. Sherman,
  • Kaisorn L. Chaichana

摘要

Purpose

While clinical outcomes of glioblastoma (GBM) are well-documented, its socio-economic impact, particularly on return to work (RTW) remains unexplored. In this study we aimed to identify the predictors of RTW at 6 months postoperatively in patients undergoing GBM treatment and to assess its association with post-operative neurological deficits and median overall survival (mOS).

Methods

We retrospectively studied 106 adults with pre-operative employment, undergoing primary GBM resection or biopsy at three tertiary centers. RTW at 3 and 6 months postoperatively were assessed using univariate and multivariate analyses.

Results

After 6 months 33 patients (33.1%) were able to RTW. Factors associated with lower odds of RTW included female sex (p = 0.039), Karnofsky Performance Scale (KPS) < 80 at 2 weeks (p = 0.034), and 3 months post-operatively (p = 0.0001), right handedness (p = 0.038), and subtotal resection (p = 0.042). On multivariate analysis female sex (OR 0.238, 95% CI 0.077–0.733, p = 0.012) and three-month postoperative KPS < 80 (OR 0.019, 95% CI 0.001–0.0293, p = 0.004) were the least likely to RTW at six months. Acute postoperative motor (p = 0.047), gait (p = 0.008) and cognitive deficits (p = 0.048) and persistent motor (p = 0.017), gait (p = 0.033) and language (p = 0.026) deficits were all associated with lesser RTW. Patients who returned to work had significantly longer mOS (21.44, p < 0.001).

Conclusions

RTW at 6 months post GBM Surgery corelates with improved mOS. Female sex and lower post-operative KPS scores were the strongest predictors of reduced RTW.