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<p><b>Objective. </b>To determine the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) in improving chronic motor aphasia after ischemic stroke (IS) in comparison with memantine. <b>Materials and methods.</b> A randomized, open, parallel-group study was conducted at the Urgench Rehabilitation Hospital in Urgench from February 2022 to May 2024. Patients with post-IS motor aphasia were randomly assigned to two groups. Group 1 (<i>n</i> = 30) received a low-frequency (1 Hz) rTMS protocol consisting of 10 sessions. Patients in Group 2 (<i>n</i> = 30) received memantine (starting dose 5 mg/day, increasing to 20 mg/day) for eight weeks. Patients were assessed using the Western Aphasia Battery (WAB) before and after intervention. <b>Results.</b> Within-group pre- and post-treatment comparison identified significant increases in each section of the WAB scale in both groups (<i>p</i> &lt; 0.001). As compared with the memantine group, the low-frequency rTMS group demonstrated greater improvements in word repetition and object naming (<i>p</i> &lt; 0.001). <b>Conclusions.</b> Both memantine and rTMS improved language function in patients with post-stroke motor aphasia. As compared with memantine, rTMS led to greater improvement in repetition and naming.</p>

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Comparison of the Effects of Transcranial Magnetic Stimulation and Memantine on Motor Aphasia in Ischemic Stroke Patients

  • 期刊论文

  • 发表日期：

    2026年7月27日

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  • A. U. Yusupov,
  • I. A. Kilichev,
  • N. Yu. Khudayberganov

摘要

Objective. To determine the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) in improving chronic motor aphasia after ischemic stroke (IS) in comparison with memantine. Materials and methods. A randomized, open, parallel-group study was conducted at the Urgench Rehabilitation Hospital in Urgench from February 2022 to May 2024. Patients with post-IS motor aphasia were randomly assigned to two groups. Group 1 (n = 30) received a low-frequency (1 Hz) rTMS protocol consisting of 10 sessions. Patients in Group 2 (n = 30) received memantine (starting dose 5 mg/day, increasing to 20 mg/day) for eight weeks. Patients were assessed using the Western Aphasia Battery (WAB) before and after intervention. Results. Within-group pre- and post-treatment comparison identified significant increases in each section of the WAB scale in both groups (p < 0.001). As compared with the memantine group, the low-frequency rTMS group demonstrated greater improvements in word repetition and object naming (p < 0.001). Conclusions. Both memantine and rTMS improved language function in patients with post-stroke motor aphasia. As compared with memantine, rTMS led to greater improvement in repetition and naming.