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<p>The effects of transglutaminase (TG) are mediated via modification of cytoskeletal proteins and small G proteins, epigenetic changes, and influences on neurogenesis, making it a versatile regulator of plasticity. However, despite the widespread occurrence of TG in invertebrates, its presence and functions in terrestrial snails remain largely unexplored. The aim of the present study was to investigate the influence of TG activity on the maintenance and reconsolidation of long-term contextual memory in the common snail <i>Helix lucorum</i>. This study addressed the effects of the TG inhibitor monodansylcadaverine and found that TG is a critical component of long-term contextual memory maintenance in <i>Helix lucorum</i>. Inhibition of TG without reactivation caused irreversible memory loss, whereas blockade of TG combined with a reminder produced no memory impairment, highlighting the key role of TG in the maintenance phase, but not the reconsolidation phase. These results can be explained by the ability of TG to act as a regulator of gene expression, though the specific target genes and mechanisms of transcriptional regulation remain to be identified.</p>

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The Contribution of Transglutaminase-Mediated Processes to the Maintenance and Reconsolidation of Long-Term Context Memory in Snails

  • 期刊论文

  • 发表日期：

    2026年2月24日

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  • A. B. Zuzina,
  • A. Kh. Vinarskaya,
  • P. M. Balaban

摘要

The effects of transglutaminase (TG) are mediated via modification of cytoskeletal proteins and small G proteins, epigenetic changes, and influences on neurogenesis, making it a versatile regulator of plasticity. However, despite the widespread occurrence of TG in invertebrates, its presence and functions in terrestrial snails remain largely unexplored. The aim of the present study was to investigate the influence of TG activity on the maintenance and reconsolidation of long-term contextual memory in the common snail Helix lucorum. This study addressed the effects of the TG inhibitor monodansylcadaverine and found that TG is a critical component of long-term contextual memory maintenance in Helix lucorum. Inhibition of TG without reactivation caused irreversible memory loss, whereas blockade of TG combined with a reminder produced no memory impairment, highlighting the key role of TG in the maintenance phase, but not the reconsolidation phase. These results can be explained by the ability of TG to act as a regulator of gene expression, though the specific target genes and mechanisms of transcriptional regulation remain to be identified.