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<p>The results of some preclinical and clinical studies have indicated that neuropeptides could be relevant in the therapy of anxiety disorders. The anxiolytic-like effect of neuropeptide S (NPS) when administered centrally or intranasally was observed in behavioral tests on naïve rodents. To date, the intranasal administration of NPS in stressed rodents has not yet been analyzed. The aim of this study was to evaluate the behavior of stressed rats that were exposed to NPS (48 PND, 2&#xa0;h after the intranasal administration, dose: 56&#xa0;nmol) and any alterations in the oxytocin (OT) and arginine-vasopressin (AVP) mRNA expression in the hypothalamus. In this study, rats were exposed to acute stress between postnatal days (PNDs) 45 and 47. Rats had been exposed to NPS (48 PND, 2&#xa0;h after the intranasal administration, dose: 56&#xa0;nmol). The behavioral effect and alterations in the oxytocin (OT) and arginine-vasopressin (AVP) mRNA expression levels in the hypothalamus are noted. It is known that OT and AVP can regulate the response to stress due to their influence on, among others, the HPA axis activity and neuropeptidergic signaling in the limbic system (complex central mechanisms). In the elevated plus-maze test (EPM), NPS attenuated the anxiety-like behavior that had been induced by acute stress. The behavioral effects were accompanied by altered expression (downregulation) of AVP and OT mRNA in the hypothalamus. Our findings indicate that NPS induced anti-anxiety effects 2&#xa0;h after intranasal administration. The mechanism of this phenomenon could be partially mediated by changes in the expression of studied nonapeptides.</p> Graphical Abstract <p></p>

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Intranasally administered neuropeptide S attenuated anxiogenic effect of acute stress with alterations in mRNA expression of nonapeptides in pubertal male rats: preliminary report

  • 期刊论文

  • 发表日期：

    2026年2月20日

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  • Miłosz Gołyszny,
  • Michał Zieliński

摘要

The results of some preclinical and clinical studies have indicated that neuropeptides could be relevant in the therapy of anxiety disorders. The anxiolytic-like effect of neuropeptide S (NPS) when administered centrally or intranasally was observed in behavioral tests on naïve rodents. To date, the intranasal administration of NPS in stressed rodents has not yet been analyzed. The aim of this study was to evaluate the behavior of stressed rats that were exposed to NPS (48 PND, 2 h after the intranasal administration, dose: 56 nmol) and any alterations in the oxytocin (OT) and arginine-vasopressin (AVP) mRNA expression in the hypothalamus. In this study, rats were exposed to acute stress between postnatal days (PNDs) 45 and 47. Rats had been exposed to NPS (48 PND, 2 h after the intranasal administration, dose: 56 nmol). The behavioral effect and alterations in the oxytocin (OT) and arginine-vasopressin (AVP) mRNA expression levels in the hypothalamus are noted. It is known that OT and AVP can regulate the response to stress due to their influence on, among others, the HPA axis activity and neuropeptidergic signaling in the limbic system (complex central mechanisms). In the elevated plus-maze test (EPM), NPS attenuated the anxiety-like behavior that had been induced by acute stress. The behavioral effects were accompanied by altered expression (downregulation) of AVP and OT mRNA in the hypothalamus. Our findings indicate that NPS induced anti-anxiety effects 2 h after intranasal administration. The mechanism of this phenomenon could be partially mediated by changes in the expression of studied nonapeptides.

Graphical Abstract