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<p>The complex effects of i.p. memantine (an NMDA receptor antagonist, dose 50 mg/kg) for seven days were demonstrated in mice of two strains differing in relative brain weight (large brain and small brain, LB and SB). Memantine enhanced exploratory behavior and reactions to novelty in LB (but not SB) mice. SB mice of the control group given physiological saline performed the test more successfully than control LB mice. Memantine had differential effects on performance on the cognitive permanence test in LB and SB mice: it maintained test performance in SB mice at a stable, sustainable level, whereas LB mice showed a sharp decrease in performance on the most “difficult” test presentations. LB (but not SB) mice had significantly more new neural cells in the subgranular zone of the dentate gyrus of the hippocampus after administration of memantine as compared with the control group. Intact LB and SB mice of the generation studied here showed no statistically significant between-strain differences in performance of the cognitive test. As these differences appeared after administration of memantine, this may be evidence of genotype-dependent differences in the behavior of LB and SB mice.</p>

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Effects of High-Dose Memantine on Behavior in Mice with Different Brain Weights

  • 期刊论文

  • 发表日期：

    2026年1月26日

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  • N. A. Ogienko,
  • A. V. Revishchin,
  • G. V. Pavlova,
  • O. V. Perepelkina,
  • I. I. Poletaeva

摘要

The complex effects of i.p. memantine (an NMDA receptor antagonist, dose 50 mg/kg) for seven days were demonstrated in mice of two strains differing in relative brain weight (large brain and small brain, LB and SB). Memantine enhanced exploratory behavior and reactions to novelty in LB (but not SB) mice. SB mice of the control group given physiological saline performed the test more successfully than control LB mice. Memantine had differential effects on performance on the cognitive permanence test in LB and SB mice: it maintained test performance in SB mice at a stable, sustainable level, whereas LB mice showed a sharp decrease in performance on the most “difficult” test presentations. LB (but not SB) mice had significantly more new neural cells in the subgranular zone of the dentate gyrus of the hippocampus after administration of memantine as compared with the control group. Intact LB and SB mice of the generation studied here showed no statistically significant between-strain differences in performance of the cognitive test. As these differences appeared after administration of memantine, this may be evidence of genotype-dependent differences in the behavior of LB and SB mice.