Scholarlink

<p>Exogenous lithium (Li) has mood-stabilizing and neuroprotective effects, but endogenous Li’s role in AD is unclear. Aron et al<i>.</i> found early endogenous Li deficiency in AD, which activates GSK3β, exacerbating AD pathology. Low-dose lithium orotate (LiO) protects against AD and age-related brain changes. Unresolved questions, like Li’s role in other brain diseases, need further study.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Endogenous lithium deficiency: a potential early contributor to Alzheimer’s disease onset

  • 期刊论文

  • 发表日期：

    2026年1月14日

查看全文
  • Shu Feng,
  • Luodan Yang

摘要

Exogenous lithium (Li) has mood-stabilizing and neuroprotective effects, but endogenous Li’s role in AD is unclear. Aron et al. found early endogenous Li deficiency in AD, which activates GSK3β, exacerbating AD pathology. Low-dose lithium orotate (LiO) protects against AD and age-related brain changes. Unresolved questions, like Li’s role in other brain diseases, need further study.