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<p>Research into the genetic basis of post-traumatic stress disorder (PTSD) may be of value in predicting the risk of its development in people who have experienced severe traumatic stress and has the potential to contribute to earlier detection of the disorder for referral to a specialist. The aim of the present work was to review all GWAS studies on PTSD. A total of 20 studies were included, including five meta-analyses; nine were conducted on war veterans. The functions of genes and their associations were considered, including single-nucleotide polymorphisms in different groups of genes involved in embryogenesis, neuron formation, and cell functioning, along with many DNA sequences from which non-coding RNA is transcribed. The reproducibility of results between studies and on replicative samples was assessed. Between studies, associations in the genes <i>CAMKV</i>, <i>CDHR4</i>, <i>DCC</i>, <i>FAM120A</i>, <i>FOXP2</i> (three studies), <i>MAD1L1</i> (three studies), <i>MAPT</i>, <i>NCAM1</i>, <i>ACTN1</i>, <i>SP4</i>, <i>ZMYM4</i>, and <i>TCF4</i> were repeated. A new and large-scale study in which multiple associations were detected is considered separately. Studies on polygenic risk were examined; more than one demonstrated genetic comorbidity with anxiety and bipolar disorder. However, the models developed by authors explain only a small percentage of variance and were poorly reproduced in other cohorts. This problem can probably be solved by using larger cohorts and clearer and more homogeneous inclusion criteria. Thus, there are as yet few GWAS studies of PTSD; they are ambiguous and uninformative as compared with analogous studies for other mental disorders, though they have further potential for assessing the risks of developing the disease.</p>

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Genetic Variants Associated with the Development of Stress Disorders: A Systematic Review of GWAS

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Ya. A. Zorkina,
  • E. A. Golubeva,
  • O. I. Gurina,
  • A. M. Reznik,
  • A. Yu. Morozova

摘要

Research into the genetic basis of post-traumatic stress disorder (PTSD) may be of value in predicting the risk of its development in people who have experienced severe traumatic stress and has the potential to contribute to earlier detection of the disorder for referral to a specialist. The aim of the present work was to review all GWAS studies on PTSD. A total of 20 studies were included, including five meta-analyses; nine were conducted on war veterans. The functions of genes and their associations were considered, including single-nucleotide polymorphisms in different groups of genes involved in embryogenesis, neuron formation, and cell functioning, along with many DNA sequences from which non-coding RNA is transcribed. The reproducibility of results between studies and on replicative samples was assessed. Between studies, associations in the genes CAMKV, CDHR4, DCC, FAM120A, FOXP2 (three studies), MAD1L1 (three studies), MAPT, NCAM1, ACTN1, SP4, ZMYM4, and TCF4 were repeated. A new and large-scale study in which multiple associations were detected is considered separately. Studies on polygenic risk were examined; more than one demonstrated genetic comorbidity with anxiety and bipolar disorder. However, the models developed by authors explain only a small percentage of variance and were poorly reproduced in other cohorts. This problem can probably be solved by using larger cohorts and clearer and more homogeneous inclusion criteria. Thus, there are as yet few GWAS studies of PTSD; they are ambiguous and uninformative as compared with analogous studies for other mental disorders, though they have further potential for assessing the risks of developing the disease.