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<p><b>Objective.</b> To study the associations of single-nucleotide polymorphisms of the <i>NOS1AP</i> gene with the duration of the QT interval in patients with schizophrenia taking antipsychotics. <b>Materials and methods.</b> A total of 168 patients (78 men and 90 women) diagnosed with schizophrenia were examined. The study patients received basic antipsychotic therapy. Standard 12-lead electrocardiograms were recorded on admission to hospital. The QTc interval was calculated using the Bazett formula. Three single nucleotide polymorphisms of the <i>NOS1AP</i> gene (rs12029454, rs10494366, and rs12143842) were selected for genotyping. <b>Results.</b> Application of the Spearman test identified a statistically significant correlation between chlorpromazine equivalent (CPZeq) and the duration of the QTc interval in the group of men (r<sub>s</sub> = 0.262; <i>p</i> = 0.021; <i>p</i><sub>bonf</sub> = 0.042). In addition, correlation analysis showed that in men with the AA and AG rs12029454 (r<sub>s</sub> = 0.717; <i>p</i> = 0.00025; <i>p</i><sub>bonf</sub> = 0.0015), GG and GT rs10494366 (r<sub>s</sub> = 0.381; <i>p</i> = 0.008; <i>p</i><sub>bonf</sub> = 0.048), and TT and CT rs12143842 (r<sub>s</sub> = 0.389; <i>p</i> = 0.003; <i>p</i><sub>bonf</sub> = 0.018) genotypes, CPZeq correlated positively with QTc interval duration. No significant correlations were found in the group of women. <b>Conclusions.</b> Polymorphic variants rs12029454, rs10494366 and rs12143842 of the <i>NOS1AP</i> gene are associated with QTc interval duration in male patients with schizophrenia in response to antipsychotics. Carriership of the AA/AG rs12029454, GG/GT rs10494366, and TT/CT rs12143842 genotypes in men contributes to prolongation of the QTc interval and the development of adverse cardiovascular events during antipsychotic therapy.</p>

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Association of NOS1AP Single-Nucleotide Gene Polymorphisms with the Duration of the QT Interval in Patients with Schizophrenia Receiving Antipsychotic Therapy

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • E. G. Kornetova,
  • S. A. Galkin,
  • I. A. Mednova,
  • V. V. Tiguntsev,
  • D. Z. Paderina,
  • S. A. Ivanova

摘要

Objective. To study the associations of single-nucleotide polymorphisms of the NOS1AP gene with the duration of the QT interval in patients with schizophrenia taking antipsychotics. Materials and methods. A total of 168 patients (78 men and 90 women) diagnosed with schizophrenia were examined. The study patients received basic antipsychotic therapy. Standard 12-lead electrocardiograms were recorded on admission to hospital. The QTc interval was calculated using the Bazett formula. Three single nucleotide polymorphisms of the NOS1AP gene (rs12029454, rs10494366, and rs12143842) were selected for genotyping. Results. Application of the Spearman test identified a statistically significant correlation between chlorpromazine equivalent (CPZeq) and the duration of the QTc interval in the group of men (rs = 0.262; p = 0.021; pbonf = 0.042). In addition, correlation analysis showed that in men with the AA and AG rs12029454 (rs = 0.717; p = 0.00025; pbonf = 0.0015), GG and GT rs10494366 (rs = 0.381; p = 0.008; pbonf = 0.048), and TT and CT rs12143842 (rs = 0.389; p = 0.003; pbonf = 0.018) genotypes, CPZeq correlated positively with QTc interval duration. No significant correlations were found in the group of women. Conclusions. Polymorphic variants rs12029454, rs10494366 and rs12143842 of the NOS1AP gene are associated with QTc interval duration in male patients with schizophrenia in response to antipsychotics. Carriership of the AA/AG rs12029454, GG/GT rs10494366, and TT/CT rs12143842 genotypes in men contributes to prolongation of the QTc interval and the development of adverse cardiovascular events during antipsychotic therapy.