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<p>Oxygen–helium mixtures demonstrate marked efficacy in animal models of ischemia/reperfusion, opening up the possibility of using helium mixtures as an emergency measure for the treatment of vascular embolism. We modeled cerebral arterial air embolism by introducing an air bubble into the internal carotid artery of awake rats. Inhalation of a warmed oxygen–helium mixture in the first hour after modeling arterial embolism normalized deviations in physiological values and prevented ischemic damage to the brain, while the use of warmed oxygen–helium mixture 2 h after modeling arterial embolism significantly aggravated the animals’ condition.</p>

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Interval Inhalational Application of an Oxygen–Helium Mixture Reverses the Effects of Cerebral Arterial Air Embolism in Rats

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • V. A. Palikov,
  • N. B. Pavlov,
  • A. M. Ismailova,
  • R. R. Amirov,
  • I. A. Dyachenko,
  • N. A. Borozdina,
  • A. V. Bervinova,
  • A. T. Logunov,
  • A. N. Murashev,
  • V. M. Baranov

摘要

Oxygen–helium mixtures demonstrate marked efficacy in animal models of ischemia/reperfusion, opening up the possibility of using helium mixtures as an emergency measure for the treatment of vascular embolism. We modeled cerebral arterial air embolism by introducing an air bubble into the internal carotid artery of awake rats. Inhalation of a warmed oxygen–helium mixture in the first hour after modeling arterial embolism normalized deviations in physiological values and prevented ischemic damage to the brain, while the use of warmed oxygen–helium mixture 2 h after modeling arterial embolism significantly aggravated the animals’ condition.