<p>Hippocampus is a structure, different parts of which are involved in processing different information. The aim of the present study was to examine the transcriptome in different parts of the mouse hippocampus after contextual fear conditioning training. We established that differential expression of 818 genes was observed in the dorsal CA1 area, 501 genes in the ventral CA1 area, 65 genes in the dorsal dentate gyrus and 91 genes in ventral dentate gyrus. According to our data, we have shown for the first time a significant change in the expression of genes encoding the acetylcholine receptors and collagen in the dorsal CA1 area due to context fear conditioning.</p>

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Changes in gene expression in dorsal and ventral CA1 areas and dentate gyrus in male mice hippocampus due to context fear conditioning

  • Natalia Bal,
  • Alexander Beletskiy,
  • Maria Volobueva,
  • Violetta Ivanova,
  • Anastasia Shvadchenko

摘要

Hippocampus is a structure, different parts of which are involved in processing different information. The aim of the present study was to examine the transcriptome in different parts of the mouse hippocampus after contextual fear conditioning training. We established that differential expression of 818 genes was observed in the dorsal CA1 area, 501 genes in the ventral CA1 area, 65 genes in the dorsal dentate gyrus and 91 genes in ventral dentate gyrus. According to our data, we have shown for the first time a significant change in the expression of genes encoding the acetylcholine receptors and collagen in the dorsal CA1 area due to context fear conditioning.