<p>Low-resistivity wells in southern Sichuan shale gas reservoirs exhibit significant variations in gas content. While most of these wells produce minimal gas, a few wells with low resistivity surprisingly yield higher production. This disparity suggests the formation differences between the two in terms of micro-genetic mechanism, macro-controlling factors, and micro–macro matching patterns. Thus, we conducted a series of analyses on shale samples from the Wufeng–Longmaxi Formations in the Changning area of the southern Sichuan Basin. Building on the results and integrating well logging data, we systematically investigated the micro-scale genetic mechanisms and macro-scale controlling factors of low-resistivity shale gas reservoirs, different micro–macro matching patterns, and the gas content characteristics under various patterns. The results demonstrate that the micro-genetic mechanism of low-resistivity shale gas reservoirs is predominantly related to elevated levels of conductive minerals (e.g., pyrite and clay minerals), organic matter graphitization, and high water saturation. Notably, organic matter graphitization and high water saturation play a crucial role in significantly reducing resistivity. The macro-scale controlling factors associated with the above micro-genetic mechanism are primarily shaped by the combined effects of sedimentation, diagenesis, and tectonic evolution. Based on the micro-genetic mechanisms and corresponding macro-scale controlling factors, three micro–macro matching patterns have been identified. The normal resistivity pattern, characterized by moderate thermal evolution and weak tectonic activity, exhibited the highest gas content, followed by the low resistivity pattern with high-to-moderate thermal evolution and weak tectonic activity. The ultra-low resistivity pattern, associated with strong thermal evolution and intense tectonic activity, had the lowest gas content. Our study not only indicates that the low-resistivity shale gas in the NX27 well area of the Changning area in southern Sichuan Basin has good gas-bearing properties but it also provides guidance for the exploration and development of low-resistivity shale gas reservoirs in other parts of the southern Sichuan Basin.</p>