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<p>The precise quantification of curcumin is critical for pharmacological and clinical quality control due to its extensive therapeutic properties. In this study, a highly sensitive electrochemical sensor was fabricated by electropolymerizing bromocresol purple onto a silver nanoparticle and multi-walled carbon nanotube (Ag/MWCNT) nanocomposite-modified carbon paste electrode. Surface characterization via SEM, TEM, and XRD confirmed the formation of a uniform, porous nanostructure, which enhanced the electroactive surface area to 0.07 cm<sup>2</sup>, a threefold increase compared to conventional carbon paste electrodes. Electrochemical investigations revealed that the sensor facilitates the electro-oxidation of curcumin via an adsorption-controlled, two-electron/two-proton mechanism. Under optimized differential pulse voltammetry conditions, the sensor exhibited a broad linear dynamic range from 0.06 to 3.07&#xa0;µM, with a low detection limit (DL) of 0.017&#xa0;µM and a quantification limit (QL) of 0.05&#xa0;µM. In addition, the proposed platform demonstrated excellent stability, reproducibility, and high selectivity against common interferents. The method showed outstanding reproducibility (RSD ≤ 2.5%) and long-term stability, retaining 96% of its initial response after 14&#xa0;days. Furthermore, the developed sensor was successfully applied for the quantification of curcumin in <i>Curcuma longa</i> and <i>Curcuma xanthorrhiza</i> rhizomes, proving its viability as a robust, low-cost tool for routine analysis.</p>

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Highly sensitive poly(bromocresol purple)/Ag-MWCNT nanocomposite-modified carbon paste electrode for the quantification of curcumin in rhizome extracts

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • A. Vijaya Bhaskar Reddy,
  • V. Madhavi,
  • Mohammed E. Ali Mohsin,
  • Suleiman Mousa

摘要

The precise quantification of curcumin is critical for pharmacological and clinical quality control due to its extensive therapeutic properties. In this study, a highly sensitive electrochemical sensor was fabricated by electropolymerizing bromocresol purple onto a silver nanoparticle and multi-walled carbon nanotube (Ag/MWCNT) nanocomposite-modified carbon paste electrode. Surface characterization via SEM, TEM, and XRD confirmed the formation of a uniform, porous nanostructure, which enhanced the electroactive surface area to 0.07 cm2, a threefold increase compared to conventional carbon paste electrodes. Electrochemical investigations revealed that the sensor facilitates the electro-oxidation of curcumin via an adsorption-controlled, two-electron/two-proton mechanism. Under optimized differential pulse voltammetry conditions, the sensor exhibited a broad linear dynamic range from 0.06 to 3.07 µM, with a low detection limit (DL) of 0.017 µM and a quantification limit (QL) of 0.05 µM. In addition, the proposed platform demonstrated excellent stability, reproducibility, and high selectivity against common interferents. The method showed outstanding reproducibility (RSD ≤ 2.5%) and long-term stability, retaining 96% of its initial response after 14 days. Furthermore, the developed sensor was successfully applied for the quantification of curcumin in Curcuma longa and Curcuma xanthorrhiza rhizomes, proving its viability as a robust, low-cost tool for routine analysis.