<p>A pillararene functionalized reduced graphene oxide was developed for the efficient electrochemical detection of bisphenol A (BPA), an emerging pollutant and endocrine disruptor in the environment. This work demonstrates the synergistic construction of nanohybrid material by supramolecular functionalization and simultaneous green reduction of graphene oxide. A novel sensing platform, pillar[6]arene/rGO/GCE combining the host–guest recognition capability of pillar[6]arene and the excellent electrical conductivity of rGO, for highly sensitive electrochemical detection of BPA in real-world samples like thermal paper extract, packaged drinking water and river water is achieved. Under optimized conditions, DPV exhibited well-defined anodic oxidation of BPA over a broad linear range of 0.05 to 10&#xa0;µM, with a low detection limit of 10&#xa0;nM, quantitation limit of 33&#xa0;nM, and a good sensitivity of 8.97 μA μM⁻¹ cm². Overall, the proposed sensor demonstrated satisfying linear range, sensitivity, selectivity, and stability highlighting its reliability for environmental monitoring of BPA.</p> Graphical Abstract <p></p>