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<p>In this work, we developed a novel fluorescent glucose sensor based on boron and nitrogen co-doped carbon dots (BN-CDs) functionalized with 2-formylphenylboronic acid (2-FPBA) via a facile one-step hydrothermal synthesis followed by condensation grafting. The resulting BN-CD/2-FPBA nanocomposite exhibits excellent water solubility, high fluorescence stability, and superior selectivity toward glucose through a turn-off fluorescence mechanism. Unlike conventional enzyme-based or heavy-metal-containing quantum dot sensors, our system leverages the intrinsic Lewis acid properties of B atoms and the synergistic effects of B, N co-doping to achieve specific glucose recognition with minimal interference from common biomolecules and ions. The sensor demonstrates a wide linear detection range of 100–4000&#xa0;μM and a low detection limit of 77.17&#xa0;μM. This work not only presents a robust, enzyme-free platform for glucose monitoring but also offers a generalizable functionalization strategy for designing high-performance carbon dot-based biosensors.</p>

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2-Formylphenylboronic acid functionalized B, N co-doped carbon dots for glucose sensor by the fluorescence turn off process

  • 期刊论文

  • 发表日期：

    2025年10月3日

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  • Jiayi Luo,
  • Taixian Wang,
  • Wen Guo,
  • Jiaxin Xu,
  • Muting Zheng,
  • Danying Zuo,
  • Hongwei Zhang

摘要

In this work, we developed a novel fluorescent glucose sensor based on boron and nitrogen co-doped carbon dots (BN-CDs) functionalized with 2-formylphenylboronic acid (2-FPBA) via a facile one-step hydrothermal synthesis followed by condensation grafting. The resulting BN-CD/2-FPBA nanocomposite exhibits excellent water solubility, high fluorescence stability, and superior selectivity toward glucose through a turn-off fluorescence mechanism. Unlike conventional enzyme-based or heavy-metal-containing quantum dot sensors, our system leverages the intrinsic Lewis acid properties of B atoms and the synergistic effects of B, N co-doping to achieve specific glucose recognition with minimal interference from common biomolecules and ions. The sensor demonstrates a wide linear detection range of 100–4000 μM and a low detection limit of 77.17 μM. This work not only presents a robust, enzyme-free platform for glucose monitoring but also offers a generalizable functionalization strategy for designing high-performance carbon dot-based biosensors.