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<p>Chlorhexidine gluconate (CHX) is an antiseptic often preferred for wound care, dental plaque prevention and treatment of fungal infections in the mouth. The aim of the study was to develop dual nanogel systems of alginate and chitosan, biocompatible polymers that can provide controlled release for the treatment of periodontitis. In this context, CHX was loaded into prepared chitosan (CS), alginate (ALG), alginate-chitosan (ALG-coated CS) and chitosan-alginate (CS-coated ALG) nanogels with high efficiency, and its structural, morphological and thermal properties were characterized. The swelling behavior, swelling kinetics and in vitro release studies of CHX-loaded nanogels in artificial saliva were carried out, and the amount of CHX was determined by high pressure liquid chromatography (HPLC). When CHX-loaded and unloaded nanogel systems were examined, it was observed that the size of CHX-unloaded nanogels varied in the range of 100–130&#xa0;nm, while the size increased with CHX loading. The nanogel systems were prepared with encapsulation efficiencies of 62% (CHX loaded CS NG), 55% (CHX-loaded ALG-coated CS NG), 75% (CHX-loaded ALG NG) and 70% (CHX-loaded CS-coated ALG NG). According to the characterization results obtained, CS, ALG, CS-coated ALG and ALG-coated CS nanogel systems can be carrier systems for the CHX drug.</p>

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The preparation and in-vitro release studies of the novel chlorhexidine gluconate loaded dual polysaccharide nanogel systems

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月27日

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  • Seçil Çavuşoğlu,
  • Ayça Mehmetoğlu Al,
  • Yeliz Yıldırım

摘要

Chlorhexidine gluconate (CHX) is an antiseptic often preferred for wound care, dental plaque prevention and treatment of fungal infections in the mouth. The aim of the study was to develop dual nanogel systems of alginate and chitosan, biocompatible polymers that can provide controlled release for the treatment of periodontitis. In this context, CHX was loaded into prepared chitosan (CS), alginate (ALG), alginate-chitosan (ALG-coated CS) and chitosan-alginate (CS-coated ALG) nanogels with high efficiency, and its structural, morphological and thermal properties were characterized. The swelling behavior, swelling kinetics and in vitro release studies of CHX-loaded nanogels in artificial saliva were carried out, and the amount of CHX was determined by high pressure liquid chromatography (HPLC). When CHX-loaded and unloaded nanogel systems were examined, it was observed that the size of CHX-unloaded nanogels varied in the range of 100–130 nm, while the size increased with CHX loading. The nanogel systems were prepared with encapsulation efficiencies of 62% (CHX loaded CS NG), 55% (CHX-loaded ALG-coated CS NG), 75% (CHX-loaded ALG NG) and 70% (CHX-loaded CS-coated ALG NG). According to the characterization results obtained, CS, ALG, CS-coated ALG and ALG-coated CS nanogel systems can be carrier systems for the CHX drug.