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<p>Dynamic light scattering (DLS) is a ubiquitous and highly standardised method that is used in the research, development, and qualification of nanoparticles. Multi-angle dynamic light scattering (MADLS) mitigates some of the limitations encountered with traditional DLS by providing better resolution for multi-modal populations and more accurate particle size distributions. MADLS has recently been gaining popularity thanks to increased access to bench-top instrumentation, but its metrology framework is not yet as advanced as for DLS, which may hinder a further uptake of MADLS method and standardisation. In this work, we utilise gold, silica, and polystyrene reference materials to provide a comparative dataset for the measurement of spherical nanoparticle hydrodynamic diameters by DLS and MADLS. We also show measurements of particle number concentration by MADLS and discuss the impact of experimental parameters such as the particle refractive index on the measurement results. This work aims to improve confidence in the use of MADLS, to benefit experimental design and, ultimately, to provide some reference data to support method verification and future standardisation.</p>

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A comparison of hydrodynamic diameter results from MADLS and DLS measurements for nanoparticle reference materials

  • 期刊论文

  • 发表日期：

    2025年6月16日

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  • Ryan T. Coones,
  • Vikram Kestens,
  • Caterina Minelli

摘要

Dynamic light scattering (DLS) is a ubiquitous and highly standardised method that is used in the research, development, and qualification of nanoparticles. Multi-angle dynamic light scattering (MADLS) mitigates some of the limitations encountered with traditional DLS by providing better resolution for multi-modal populations and more accurate particle size distributions. MADLS has recently been gaining popularity thanks to increased access to bench-top instrumentation, but its metrology framework is not yet as advanced as for DLS, which may hinder a further uptake of MADLS method and standardisation. In this work, we utilise gold, silica, and polystyrene reference materials to provide a comparative dataset for the measurement of spherical nanoparticle hydrodynamic diameters by DLS and MADLS. We also show measurements of particle number concentration by MADLS and discuss the impact of experimental parameters such as the particle refractive index on the measurement results. This work aims to improve confidence in the use of MADLS, to benefit experimental design and, ultimately, to provide some reference data to support method verification and future standardisation.