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<p>Antidepressant abuse has become a growing concern due to their bioaccumulation and potential drug resistance in the environment. Developing smart sensing platforms for antidepressant drug identification could monitor their contamination situation in time. Here, a novel boron-doped g-C<sub>3</sub>N<sub>4</sub>-glycolchitosan composite (BCNP-GC) was synthesized with high fluorescence emission and ultralong water stability. The electron-deficient boron atom greatly improves the fluorescence response of the composite, while the encapsulation of glycol-chitosan (GC) further enhances its water stability. The designed BCNP-GC could serve as a highly efficient fluorescent probe for the rapid and sensitive detection of nortriptyline (NOT), a typical antidepressant drug in the environment, via internal filtration effect and dynamic quenching effect. It is expected that this strategy can be extended to the fabrication of a variety of nitrogenous carbon-based tricyclic antidepressant monitoring systems with more customized functionalities.</p>

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Highly emissive boron-doped g-C3N4-glycolchitosan probe with ultralong stability and its application in sensitive nortriptyline monitoring

  • 期刊论文

  • 发表日期：

    2025年3月13日

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  • Chao He,
  • Shengcun Chen,
  • Min Zhang,
  • Xing Zhang,
  • Jie Zheng,
  • Lei Lin

摘要

Antidepressant abuse has become a growing concern due to their bioaccumulation and potential drug resistance in the environment. Developing smart sensing platforms for antidepressant drug identification could monitor their contamination situation in time. Here, a novel boron-doped g-C3N4-glycolchitosan composite (BCNP-GC) was synthesized with high fluorescence emission and ultralong water stability. The electron-deficient boron atom greatly improves the fluorescence response of the composite, while the encapsulation of glycol-chitosan (GC) further enhances its water stability. The designed BCNP-GC could serve as a highly efficient fluorescent probe for the rapid and sensitive detection of nortriptyline (NOT), a typical antidepressant drug in the environment, via internal filtration effect and dynamic quenching effect. It is expected that this strategy can be extended to the fabrication of a variety of nitrogenous carbon-based tricyclic antidepressant monitoring systems with more customized functionalities.