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<p>Chronic hyperkeratotic tinea pedis is a treatment-resistant infection. We evaluated the efficacy of a 3-month course of topical 1% luliconazole in 21 hyperkeratotic tinea pedis patients. The diagnosis was confirmed through microscopy and culture. The lesion area was assessed monthly using a software program. Clinical responses were classified into five categories from “cured” to “no change.” Among the isolates, one terbinafine-resistant <i>T. rubrum</i> strain was detected. The mean lesion area decreased significantly over 3&#xa0;months, with an average improvement rate of 94.1% ± 12.7% and a cure rate of 61.9%. The mean amount of luliconazole used per foot was 27.5 ± 9.7&#xa0;g monthly. The resistant case showed a partial improvement with topical luliconazole and was successfully treated with oral fosravuconazole. These findings suggest that 1% topical luliconazole is effective for treating hyperkeratotic tinea pedis.</p>

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Topical Luliconazole Treatment for Hyperkeratotic Tinea Pedis

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Sayaka Ohara,
  • Hiromitsu Noguchi,
  • Tadahiko Matsumoto,
  • Daiki Hayashi,
  • Kayo Kashiwada-Nakamura,
  • Masahide Kubo,
  • Rui Kano,
  • Satoshi Fukushima

摘要

Chronic hyperkeratotic tinea pedis is a treatment-resistant infection. We evaluated the efficacy of a 3-month course of topical 1% luliconazole in 21 hyperkeratotic tinea pedis patients. The diagnosis was confirmed through microscopy and culture. The lesion area was assessed monthly using a software program. Clinical responses were classified into five categories from “cured” to “no change.” Among the isolates, one terbinafine-resistant T. rubrum strain was detected. The mean lesion area decreased significantly over 3 months, with an average improvement rate of 94.1% ± 12.7% and a cure rate of 61.9%. The mean amount of luliconazole used per foot was 27.5 ± 9.7 g monthly. The resistant case showed a partial improvement with topical luliconazole and was successfully treated with oral fosravuconazole. These findings suggest that 1% topical luliconazole is effective for treating hyperkeratotic tinea pedis.