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<p>Cryptococcosis, a rare deep fungal infection, primarily affects immunocompromised individuals and carries a high mortality risk when hematogenously disseminated to the central nervous system (CNS). Cutaneous cryptococcosis poses diagnostic challenges due to its diverse and nonspecific dermatological manifestations. Traditional diagnostic methods, including mycological examination, culture, and histopathology, are time-consuming and require specialized expertise, often leading to misdiagnosis. Metagenomic next-generation sequencing (mNGS), an advanced molecular tool, enables rapid and unbiased pathogen identification. Here, we present the first documented case of cutaneous cryptococcosis diagnosed via mNGS, demonstrating its pivotal role in guiding timely treatment despite negative initial conventional tests.</p>

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Overcoming the Diagnostic Challenges in Cutaneous Cryptococcosis Caused by Cryptococcus neoformans: A Case Study Utilizing Metagenomic Next-Generation Sequencing

  • 期刊论文

  • 发表日期：

    2025年7月16日

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  • Liujun Lu,
  • Yulin Chen,
  • Minfang Leng,
  • Shuquan He,
  • Qunlan Liu,
  • Songyun Zou,
  • Yueming Liu,
  • Feixiang Fan

摘要

Cryptococcosis, a rare deep fungal infection, primarily affects immunocompromised individuals and carries a high mortality risk when hematogenously disseminated to the central nervous system (CNS). Cutaneous cryptococcosis poses diagnostic challenges due to its diverse and nonspecific dermatological manifestations. Traditional diagnostic methods, including mycological examination, culture, and histopathology, are time-consuming and require specialized expertise, often leading to misdiagnosis. Metagenomic next-generation sequencing (mNGS), an advanced molecular tool, enables rapid and unbiased pathogen identification. Here, we present the first documented case of cutaneous cryptococcosis diagnosed via mNGS, demonstrating its pivotal role in guiding timely treatment despite negative initial conventional tests.