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<p>Hematoxylin and eosin (H&amp;E) staining are the key sources for identifying breast cancer patterns with different colors and shapes of nuclei cells for segmenting histopathology nucleus images. In nucleus cells, the color categorization of hematoxylin is stained blue, whereas cytoplasmic cells of eosin are stained pink. This color dissimilarity in the nucleus cells indicates different structures of the cellular and cancer-specific cells, which need to detect on time is a challenge for accurate diagnosis. To overcome this issue, a Deep Convolution Neural Network (Deep-CNN) based Unet framework with Transfer Learning (TL) is proposed for segmenting histopathology breast cancer images. Specifically, the Deep-CNN framework has been used to extract features automatically from input images, and select the features by using the TL technique for minimizing the target tasks to train it faster. Furthermore, a deep convolutional-based Gaussian Mixture Model (GMM) is used to normalize the shapes and merge the nucleus cell pixels for color optimization. The proposed method has been tested on Kaggle’s 2018 Data Science Blow histopathology breast image dataset. The experimental results of the proposed scheme have been evaluated by performance evaluation matrices, namely accuracy, Jaccard coefficient, Dice Similarity Coefficient (DSC), Intersection over Union (IoU), and F1-score. The proposed approach outperforms compared with different state-of-the-art models on the same dataset.</p>

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Automated breast nuclei feature extraction for segmentation in histopathology images using Deep-CNN-based gaussian mixture model and color optimization technique

  • 期刊论文

  • 发表日期：

    2025年2月18日

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  • Anita Murmu,
  • Piyush Kumar

摘要

Hematoxylin and eosin (H&E) staining are the key sources for identifying breast cancer patterns with different colors and shapes of nuclei cells for segmenting histopathology nucleus images. In nucleus cells, the color categorization of hematoxylin is stained blue, whereas cytoplasmic cells of eosin are stained pink. This color dissimilarity in the nucleus cells indicates different structures of the cellular and cancer-specific cells, which need to detect on time is a challenge for accurate diagnosis. To overcome this issue, a Deep Convolution Neural Network (Deep-CNN) based Unet framework with Transfer Learning (TL) is proposed for segmenting histopathology breast cancer images. Specifically, the Deep-CNN framework has been used to extract features automatically from input images, and select the features by using the TL technique for minimizing the target tasks to train it faster. Furthermore, a deep convolutional-based Gaussian Mixture Model (GMM) is used to normalize the shapes and merge the nucleus cell pixels for color optimization. The proposed method has been tested on Kaggle’s 2018 Data Science Blow histopathology breast image dataset. The experimental results of the proposed scheme have been evaluated by performance evaluation matrices, namely accuracy, Jaccard coefficient, Dice Similarity Coefficient (DSC), Intersection over Union (IoU), and F1-score. The proposed approach outperforms compared with different state-of-the-art models on the same dataset.