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<p>Alzheimer’s disease (AD) is one of the most common forms of dementia. AD is associated with memory loss and cognitive decline. Several research works have been carried out to treat AD. However, currently available treatment options are only useful in the treatment of the individual pathology of AD but not useful in disease modification. Recent research works have identified the associated effects of neuroinflammation, oxidative stress, and glial cell dysfunction in AD pathology. Aspirin is one of the most commonly used NSAIDs in the treatment of several inflammatory diseases. Aspirin inhibits cyclooxygenase (COX) enzymes through an irreversible pathway. However, aspirin also exhibits other important pharmacological properties. This review aims to highlight the potential of aspirin-based multi-target directed ligands in the regulation of AD pathology through the regulation of neuroinflammation and oxidative stress.</p> Graphical abstract <p>Schematic overview of aspirin and aspirin-derived multi-target-directed ligands (MTDLs) targeting interconnected pathological processes in Alzheimer’s disease, including neuroinflammation, oxidative stress, glial&#xa0;activation, and amyloid-β–associated dysfunction.</p> <p></p>

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Aspirin as a neuroprotective scaffold in Alzheimer’s disease: inflammation, oxidative stress, and future directions

  • 期刊论文

  • 发表日期：

    2026年5月12日

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  • Kailash S,
  • Gokulavani L,
  • Pandi Prabha S,
  • Karthik C

摘要

Alzheimer’s disease (AD) is one of the most common forms of dementia. AD is associated with memory loss and cognitive decline. Several research works have been carried out to treat AD. However, currently available treatment options are only useful in the treatment of the individual pathology of AD but not useful in disease modification. Recent research works have identified the associated effects of neuroinflammation, oxidative stress, and glial cell dysfunction in AD pathology. Aspirin is one of the most commonly used NSAIDs in the treatment of several inflammatory diseases. Aspirin inhibits cyclooxygenase (COX) enzymes through an irreversible pathway. However, aspirin also exhibits other important pharmacological properties. This review aims to highlight the potential of aspirin-based multi-target directed ligands in the regulation of AD pathology through the regulation of neuroinflammation and oxidative stress.

Graphical abstract

Schematic overview of aspirin and aspirin-derived multi-target-directed ligands (MTDLs) targeting interconnected pathological processes in Alzheimer’s disease, including neuroinflammation, oxidative stress, glial activation, and amyloid-β–associated dysfunction.