<p>The liver, a vital metabolic organ with critical roles in detoxification, digestion, and metabolism, is highly susceptible to damage caused by the consumption of alcohol and drugs or infection of viruses. Persistent injury to the liver may progress to severe conditions. Flavonoid monomers, characterized by a fundamental 2-phenylchromone backbone, are a class of traditional Chinese medicine-derived natural polyphenolic compounds. These compounds can inhibit inflammation, oxidation, fibrosis, cancer, and diverse other pathological disorders pharmacologically, which are promising for the treatment of liver diseases. However, the specific mechanisms of flavonoid monomers in liver diseases remain unclear. Based on an extensive literature review, this work summarizes recent research advances on the mechanism of flavonoid monomers in liver diseases. This review is expected to provide novel insights that support the therapeutic application of flavonoid monomers in liver disease treatment.</p> Graphical abstract <p></p>