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<p>The Serine/Arginine Protein Kinase (SRPK) family plays a critical role in regulating RNA splicing and associated phosphorylation events, thereby governing essential cellular processes such as splicing regulation, proteome diversification, and signaling pathway activation. Growing evidence implicates SRPKs in the pathogenesis of various diseases, underscoring their potential as promising therapeutic targets. In this review, we systematically summarize current knowledge on the structural characteristics of SRPKs, their mechanistic involvement in disease pathogenesis, and emerging therapeutic strategies, based on comprehensive searches of databases including PubMed, Google Scholar, and X-mol. We further provide mechanistic insights into SRPK-mediated disease regulation, assess recent advances in the development of SRPK-targeted inhibitors, and discuss key challenges and future research directions in the field. This review aims to offer guidance for subsequent studies and to facilitate the translation of SRPK-related mechanisms into precision medicine applications.</p> Graphical abstract <p></p>

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From splicing to disease: the crucial role of serine/arginine protein kinases in cellular regulation

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Rilang Sa,
  • Xuemin Zhang,
  • Mandi Wu,
  • Lan Yu

摘要

The Serine/Arginine Protein Kinase (SRPK) family plays a critical role in regulating RNA splicing and associated phosphorylation events, thereby governing essential cellular processes such as splicing regulation, proteome diversification, and signaling pathway activation. Growing evidence implicates SRPKs in the pathogenesis of various diseases, underscoring their potential as promising therapeutic targets. In this review, we systematically summarize current knowledge on the structural characteristics of SRPKs, their mechanistic involvement in disease pathogenesis, and emerging therapeutic strategies, based on comprehensive searches of databases including PubMed, Google Scholar, and X-mol. We further provide mechanistic insights into SRPK-mediated disease regulation, assess recent advances in the development of SRPK-targeted inhibitors, and discuss key challenges and future research directions in the field. This review aims to offer guidance for subsequent studies and to facilitate the translation of SRPK-related mechanisms into precision medicine applications.

Graphical abstract