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Background <p>Sertoli cells are essential for spermatogenesis, controlling the microenvironment and interacting with germ cells. This study evaluates the preventive effect of alpha-tocopherol succinate against Al₂O₃-NPs-induced damage in NMRI mice Sertoli cells.</p> Methods <p>The effects of Al₂O₃-NPs and vitamin E were assessed on Sertoli cells using viability assays, oxidative stress markers, apoptosis detection, and gene expression analysis.</p> Results <p>Al₂O₃-NPs significantly reduced Sertoli cell viability and increased apoptosis, while vitamin E treatment mitigated these effects. Expression of INHBB and Cx43 was significantly downregulated by Al₂O₃-NPs and upregulated with vitamin E.</p> Conclusion <p>Vitamin E alleviates Al₂O₃-NPs-induced Sertoli cell damage by reducing oxidative stress, inhibiting apoptosis, and restoring INHBB and Cx43 expression.</p>

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Protective effect of alpha-tocopherol succinate on Al₂O₃-NPs induced damage in NMRI mice Sertoli cells: the role of inhibin B and Connexin 43

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Milad Dadgar Naki,
  • Elaheh Amini,
  • Fatemeh Rohollah

摘要

Background

Sertoli cells are essential for spermatogenesis, controlling the microenvironment and interacting with germ cells. This study evaluates the preventive effect of alpha-tocopherol succinate against Al₂O₃-NPs-induced damage in NMRI mice Sertoli cells.

Methods

The effects of Al₂O₃-NPs and vitamin E were assessed on Sertoli cells using viability assays, oxidative stress markers, apoptosis detection, and gene expression analysis.

Results

Al₂O₃-NPs significantly reduced Sertoli cell viability and increased apoptosis, while vitamin E treatment mitigated these effects. Expression of INHBB and Cx43 was significantly downregulated by Al₂O₃-NPs and upregulated with vitamin E.

Conclusion

Vitamin E alleviates Al₂O₃-NPs-induced Sertoli cell damage by reducing oxidative stress, inhibiting apoptosis, and restoring INHBB and Cx43 expression.