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<p>Dental stem cells (DSCs) have emerged as valuable tools in regenerative medicine due to their ability to differentiate into various cell types, including adipocytes. Although their adipogenic potential is generally described as modest or lower compared with mesenchymal stem cells from other sources, DSCs remain useful in <i>vitro</i> models for studying the mechanisms underlying adipose tissue formation. This review highlights recent advances in the epigenetic regulation of adipogenesis, including insights from histone modifications, particularly H3K9, which we contextualize within the broader landscape of epigenetic regulation in DSCs and other mesenchymal stem cells (MSCs). Additionally, the effects of epigenetic drugs are analyzed, and differences in adipogenic commitment among various types of DSCs are discussed. These findings underscore their importance as models for designing therapies targeting metabolic diseases.</p>

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Epigenetic regulation of adipogenesis on dental stem cells: a focus on histone modifications

  • 期刊论文

  • 发表日期：

    2026年2月9日

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  • Julio A. Montero-Del-Toro,
  • Angelica A. Serralta-Interian,
  • Julio C. Torres-Romero,
  • Rafael Rojas-Herrera,
  • Beatriz A. Rodas-Junco

摘要

Dental stem cells (DSCs) have emerged as valuable tools in regenerative medicine due to their ability to differentiate into various cell types, including adipocytes. Although their adipogenic potential is generally described as modest or lower compared with mesenchymal stem cells from other sources, DSCs remain useful in vitro models for studying the mechanisms underlying adipose tissue formation. This review highlights recent advances in the epigenetic regulation of adipogenesis, including insights from histone modifications, particularly H3K9, which we contextualize within the broader landscape of epigenetic regulation in DSCs and other mesenchymal stem cells (MSCs). Additionally, the effects of epigenetic drugs are analyzed, and differences in adipogenic commitment among various types of DSCs are discussed. These findings underscore their importance as models for designing therapies targeting metabolic diseases.