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Background <p>Thyroid hormones are mainly concerning with regulation of organs metabolism. Hypothyroidism is a pathological condition characterized by decrease of T3 and T4 level that negatively impact various organs especially liver and lung. Dapagliflozin (DAPA) is an anti diabetic drug posses antioxidant and anti apoptotic properties</p> Aim of the study <p>The aim of this work is to identify the effect of DAPA on disturbance of liver and lung functions result from hypothyroidism</p> Materials and methods <p>Twenty four rats (6 rats/group) were divided into four groups: control group, DAPA group that received DAPA (1&#xa0;mg/kg/day for five weeks), PTU group that received propylthiouracil (15 mg/kg/day for five weeks), PTU+ DAPA group that received PTU and DAPA as described in the other groups</p> Results <p>Hypothyroidism induced oxidative stress associated mitophagy disturbance in both lung and liver with development of apoptosis in liver. DAPA avoided this effect</p> Conclusion <p>DAPA protects against liver and lung injury result from hypothyroidism.</p>

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Dapagliflozin attenuates hypothyroidism induced liver and lung dysfunction via regulation of mitophagy and apoptosis

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Marwa Abdeltawab Mohammed,
  • Esraa Mohamed Ali,
  • Manar Fouad Ahmed,
  • Sarah A. Eweda,
  • Maha Tarek Mohammed,
  • Dina Sayed Abdelrahim

摘要

Background

Thyroid hormones are mainly concerning with regulation of organs metabolism. Hypothyroidism is a pathological condition characterized by decrease of T3 and T4 level that negatively impact various organs especially liver and lung. Dapagliflozin (DAPA) is an anti diabetic drug posses antioxidant and anti apoptotic properties

Aim of the study

The aim of this work is to identify the effect of DAPA on disturbance of liver and lung functions result from hypothyroidism

Materials and methods

Twenty four rats (6 rats/group) were divided into four groups: control group, DAPA group that received DAPA (1 mg/kg/day for five weeks), PTU group that received propylthiouracil (15 mg/kg/day for five weeks), PTU+ DAPA group that received PTU and DAPA as described in the other groups

Results

Hypothyroidism induced oxidative stress associated mitophagy disturbance in both lung and liver with development of apoptosis in liver. DAPA avoided this effect

Conclusion

DAPA protects against liver and lung injury result from hypothyroidism.