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<p>The utilization of natural compounds in anticancer treatment has garnered significant attention owing to their promising therapeutic potential and minimal adverse effects compared to conventional methods. The present paper reviews three prominent groups of natural compounds: taxanes, beta-glucans, and isothiocyanates. These three groups were selected based on their clinical evidence, complementary treatment, and recent breakthroughs in delivery systems that warrant a comprehensive review of their structural attributes, biochemical characteristics, and intricate mechanisms of action in cancer. Taxanes stabilize microtubules, disrupt mitotic spindle function, and induce cancer cell apoptosis. Beta-glucans boost immune responses and inhibit cancer cell growth. Isothiocyanates modulate detoxification enzymes, inhibit carcinogens, and induce apoptosis in cancer cells. These groups of natural compounds offer promising anticancer effects and have potential as standalone or adjuvant therapies. We highlight emerging synergistic combinations among these compounds and identify crucial knowledge gaps, particularly in understanding their interactions with the tumor microenvironment and potential applications in immunotherapy-based treatment strategies. Exploring novel delivery strategies and combinatorial approaches could enhance their efficacy while minimizing adverse effects, thereby paving the way for personalized and holistic cancer treatment.</p>

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Structures, characteristics, and anticancer mechanisms of taxanes, beta-glucans, and isothiocyanates

  • 期刊论文

  • 发表日期：

    2026年1月30日

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  • Piotr Gromek,
  • Weronika Kruczkowska,
  • Kacper Górecki,
  • Julia Gałęziewska,
  • Elżbieta Płuciennik,
  • Łukasz Janczewski,
  • Mateusz Kciuk,
  • Lin-Yong Zhao,
  • Zbigniew Pasieka,
  • Żaneta Kałuzińska-Kołat,
  • Damian Kołat

摘要

The utilization of natural compounds in anticancer treatment has garnered significant attention owing to their promising therapeutic potential and minimal adverse effects compared to conventional methods. The present paper reviews three prominent groups of natural compounds: taxanes, beta-glucans, and isothiocyanates. These three groups were selected based on their clinical evidence, complementary treatment, and recent breakthroughs in delivery systems that warrant a comprehensive review of their structural attributes, biochemical characteristics, and intricate mechanisms of action in cancer. Taxanes stabilize microtubules, disrupt mitotic spindle function, and induce cancer cell apoptosis. Beta-glucans boost immune responses and inhibit cancer cell growth. Isothiocyanates modulate detoxification enzymes, inhibit carcinogens, and induce apoptosis in cancer cells. These groups of natural compounds offer promising anticancer effects and have potential as standalone or adjuvant therapies. We highlight emerging synergistic combinations among these compounds and identify crucial knowledge gaps, particularly in understanding their interactions with the tumor microenvironment and potential applications in immunotherapy-based treatment strategies. Exploring novel delivery strategies and combinatorial approaches could enhance their efficacy while minimizing adverse effects, thereby paving the way for personalized and holistic cancer treatment.