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<p><i>Angiopoietin-like 7 (ANGPTL7)</i> is a member of the angiopoietin-like protein family, which plays critical physiological roles in angiogenesis, tissue homeostasis maintenance, inflammatory signaling, glucose metabolism and lipid metabolism. Meanwhile, <i>ANGPTL7</i> is also implicated in the regulation of numerous pathological processes and disease development. In recent years, several studies have demonstrated that <i>ANGPTL7</i> is differentially expressed in various types of tumors and it may regulate tumourigenesis, tumor angiogenesis, invasion, and metastasis through diverse mechanisms. Additionally, <i>ANGPTL7</i> has been implicated in the diagnosis and prognosis of tumor patients, suggesting its potential as a novel biomarker for tumor prediction. In this review, we provide a comprehensive overview of the structure and function of <i>ANGPTL7</i>, as well as its role and underlying mechanisms in tumor development. Furthermore, we discuss potential future research directions and clinical applications of <i>ANGPTL7</i> in oncology.</p>

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Mechanisms of angiopoietin-like protein 7 regulation and therapeutic potential in tumors

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • Xiaoxiao Fan,
  • Wenxin Zheng,
  • Xianglong Tian,
  • Xiaolin Wu

摘要

Angiopoietin-like 7 (ANGPTL7) is a member of the angiopoietin-like protein family, which plays critical physiological roles in angiogenesis, tissue homeostasis maintenance, inflammatory signaling, glucose metabolism and lipid metabolism. Meanwhile, ANGPTL7 is also implicated in the regulation of numerous pathological processes and disease development. In recent years, several studies have demonstrated that ANGPTL7 is differentially expressed in various types of tumors and it may regulate tumourigenesis, tumor angiogenesis, invasion, and metastasis through diverse mechanisms. Additionally, ANGPTL7 has been implicated in the diagnosis and prognosis of tumor patients, suggesting its potential as a novel biomarker for tumor prediction. In this review, we provide a comprehensive overview of the structure and function of ANGPTL7, as well as its role and underlying mechanisms in tumor development. Furthermore, we discuss potential future research directions and clinical applications of ANGPTL7 in oncology.