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Introduction <p>This study investigates the association between the levels of two tRNA-derived fragments, tRF-17-79MP9PP and tRF-18-79MP9P04, and the pathophysiology of prostate cancer (PCa).</p> Materials and methods <p>Forty patients were included: 8 with benign prostatic hyperplasia (BPH) and 32 with different PCa grades. Total RNA was extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissues, and the levels of tRF-17-79MP9PP and tRF-18-79MP9P04 were analyzed.</p> Results <p>The abundance of tRF-17-79MP9PP increased progressively with cancer grade (<i>p</i> &lt; 0.001), with the highest levels observed in advanced PCa. Interestingly, BPH also showed higher tRF-17-79MP9PP level than low- and mild-grade PCa. Level of tRF-18-79MP9P04 was comparable between BPH and low-grade PCa, but significantly higher in mild, high, and advanced grades (<i>p</i> &lt; 0.001). Furthermore, PSA levels were significantly correlated with both tRF-17-79MP9PP and tRF-18-79MP9P04 in PCa patients (<i>p</i> &lt; 0.001), but not in the BPH group.</p> Discussion <p>Both tRF-17-79MP9PP and tRF-18-79MP9P04 appear to play important roles in prostate cancer, demonstrating potential oncogenic behavior in advanced stages, which contrasts with previous studies reporting tumor-suppressive effects.</p> Conclusion <p>These findings indicate that elevated levels of these tRNA-derived fragments may serve as potential biomarkers for distinguishing between different grades of PCa.</p>

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Investigation of the association of tRNA-derived fragments (tRF-17-79MP9PP and tRF-18-79MP9P04) with prostate cancer

  • 期刊论文

  • 发表日期：

    2025年10月23日

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  • Sercan Ergun,
  • Kadir Önem,
  • Deniz Bayçelebi,
  • Ümmet Abur,
  • Özlem Terzi,
  • Senanur Olfaz Aslan,
  • Neslihan Taşkurt Hekim,
  • Sezgin Güneş,
  • Dilbeste Demir Yeşilyurt,
  • Yeda Keleş

摘要

Introduction

This study investigates the association between the levels of two tRNA-derived fragments, tRF-17-79MP9PP and tRF-18-79MP9P04, and the pathophysiology of prostate cancer (PCa).

Materials and methods

Forty patients were included: 8 with benign prostatic hyperplasia (BPH) and 32 with different PCa grades. Total RNA was extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissues, and the levels of tRF-17-79MP9PP and tRF-18-79MP9P04 were analyzed.

Results

The abundance of tRF-17-79MP9PP increased progressively with cancer grade (p < 0.001), with the highest levels observed in advanced PCa. Interestingly, BPH also showed higher tRF-17-79MP9PP level than low- and mild-grade PCa. Level of tRF-18-79MP9P04 was comparable between BPH and low-grade PCa, but significantly higher in mild, high, and advanced grades (p < 0.001). Furthermore, PSA levels were significantly correlated with both tRF-17-79MP9PP and tRF-18-79MP9P04 in PCa patients (p < 0.001), but not in the BPH group.

Discussion

Both tRF-17-79MP9PP and tRF-18-79MP9P04 appear to play important roles in prostate cancer, demonstrating potential oncogenic behavior in advanced stages, which contrasts with previous studies reporting tumor-suppressive effects.

Conclusion

These findings indicate that elevated levels of these tRNA-derived fragments may serve as potential biomarkers for distinguishing between different grades of PCa.