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Background <p>Obesity resulting from an energy imbalance is a key factor in the development of several comorbidities. Traditional communities have historically used insects for their nutritional and therapeutic benefits, particularly in treating chronic diseases such as diabetes and obesity. The present study explores the bee (<i>Apis mellifera</i>) powder supplementation effects on metabolic parameters in mice with diet-induced obesity.</p> Methods and Results <p>Male Swiss mice were subjected to a high-fat diet for three months, followed by a month of treatment with two different bee powder concentration additions. The animals were divided into four groups: standard diet, high-fat diet, high-fat with 15% bee powder, and high-fat with 30% bee powder. Bee powder supplementation reduced body weight and adipocyte size, promoting an increase in brown adipose tissue, decreasing glucose and cholesterol levels, and modulated the expression of FAS, ACC and GPX4.</p> Conclusion <p>These findings suggest bee powder’s potential use for therapeutic applications in treating obesity and related conditions.</p> Graphical abstract <p></p>

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Dietary supplementation with wholemeal bee powder (Apis mellifera) effect on improving metabolic parameters and modulating lipogenesis genes in diet-induced obese mice

  • 期刊论文

  • 发表日期：

    2025年7月9日

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  • Joyce Hellyen Santos Pereira,
  • Daniel Silva Moraes,
  • Aline Lopes Nascimento,
  • Bruna Kaicy Barbosa,
  • Victor Hugo Dantas Guimarães,
  • Junio Cota,
  • Lucyana Conceição Farias,
  • Alfredo Mauricio Batista de Paula,
  • André Luiz Sena Guimarães,
  • Sérgio Henrique Sousa Santos

摘要

Background

Obesity resulting from an energy imbalance is a key factor in the development of several comorbidities. Traditional communities have historically used insects for their nutritional and therapeutic benefits, particularly in treating chronic diseases such as diabetes and obesity. The present study explores the bee (Apis mellifera) powder supplementation effects on metabolic parameters in mice with diet-induced obesity.

Methods and Results

Male Swiss mice were subjected to a high-fat diet for three months, followed by a month of treatment with two different bee powder concentration additions. The animals were divided into four groups: standard diet, high-fat diet, high-fat with 15% bee powder, and high-fat with 30% bee powder. Bee powder supplementation reduced body weight and adipocyte size, promoting an increase in brown adipose tissue, decreasing glucose and cholesterol levels, and modulated the expression of FAS, ACC and GPX4.

Conclusion

These findings suggest bee powder’s potential use for therapeutic applications in treating obesity and related conditions.

Graphical abstract