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<p>This systematic review aimed to analyze the prevalence of the most common globally occurring carbapenemase genes (<i>bla</i><sub>OXA</sub>, <i>bla</i><sub>NDM</sub>, <i>bla</i><sub>KPC</sub>, <i>bla</i><sub>IMP</sub>, <i>bla</i><sub>VIM</sub>, and <i>bla</i><sub>GES</sub>) in <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i> isolated from Iranian ICUs between 2014 and 2025. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search was conducted in Embase, PubMed/MEDLINE, and Scopus databases to find relevant studies. The search resulted in 931 records; after removing articles according to the inclusion/exclusion criteria, only 10 articles were included in this study. According to the results of this review, carbapenemase-encoding <i>bla</i><sub>OXA</sub> (47%) and <i>bla</i><sub>NDM</sub> (33.6%) were most prevalent in <i>K. pneumoniae</i>, while <i>bla</i><sub>OXA</sub> was the sole gene detected in <i>E. coli</i> isolates, with a prevalence of 12.1%. The comparison revealed that <i>K. pneumoniae</i> had an OR of 6.4 (95% CI: 2.9–14.5; <i>p</i>-value &lt; 0.001) for <i>bla</i><sub>OXA</sub> prevalence compared to <i>E. coli</i>, indicating a significantly higher pooled prevalence of <i>bla</i><sub>OXA</sub> in <i>K. pneumoniae</i>. Moreover, antibiotic resistance rates to carbapenems, aminoglycosides, fluoroquinolones, and cephalosporins were significantly higher in <i>K. pneumoniae</i> compared to <i>E. coli</i> isolates. The findings emphasize the importance of finding new inhibitors to cover OXA and NDM carbapenemases and infection control strategies in the ICU setting to address the significantly high prevalence of carbapenemases in Iranian ICUs.</p>

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Prevalence of carbapenemase genes in Klebsiella pneumoniae and Escherichia coli isolated from intensive care unit patients in Iran: a systematic review (2014–2025)

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Shahnaz Halimi,
  • Maryam Siroosi

摘要

This systematic review aimed to analyze the prevalence of the most common globally occurring carbapenemase genes (blaOXA, blaNDM, blaKPC, blaIMP, blaVIM, and blaGES) in Klebsiella pneumoniae and Escherichia coli isolated from Iranian ICUs between 2014 and 2025. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search was conducted in Embase, PubMed/MEDLINE, and Scopus databases to find relevant studies. The search resulted in 931 records; after removing articles according to the inclusion/exclusion criteria, only 10 articles were included in this study. According to the results of this review, carbapenemase-encoding blaOXA (47%) and blaNDM (33.6%) were most prevalent in K. pneumoniae, while blaOXA was the sole gene detected in E. coli isolates, with a prevalence of 12.1%. The comparison revealed that K. pneumoniae had an OR of 6.4 (95% CI: 2.9–14.5; p-value < 0.001) for blaOXA prevalence compared to E. coli, indicating a significantly higher pooled prevalence of blaOXA in K. pneumoniae. Moreover, antibiotic resistance rates to carbapenems, aminoglycosides, fluoroquinolones, and cephalosporins were significantly higher in K. pneumoniae compared to E. coli isolates. The findings emphasize the importance of finding new inhibitors to cover OXA and NDM carbapenemases and infection control strategies in the ICU setting to address the significantly high prevalence of carbapenemases in Iranian ICUs.