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Background <p>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a variety of clinical manifestations and a relapsing–remitting course. MiR-338-3p has emerged as a significant regulator of the immune response in the pathogenesis of SLE. Hsa_circ_0049356 is a circular RNA that may serve as a potential biological or clinical marker for autoimmune disorders.</p> Purpose of the study <p>This study aims to evaluate the potential role of hsa_circ_0049356 and miR-338-3p in the pathogenesis of SLE by analyzing their expression patterns and assessing their impact on the ERK/MAPK signaling pathway. Understanding these interactions may provide novel insights into the pathogenesis of SLE and identify potential diagnostic or therapeutic targets.</p> Methods <p>This study included 100 participants, divided into two groups: healthy controls and SLE patients. Comprehensive clinical evaluations, including history taking, physical examination, and laboratory investigations, were performed. The expression levels of hsa_circ_0049356 and miR-338-3p were determined using RT-PCR. Additionally, the levels of SIRT6, ERK, MAPK, and MEK-1 were measured using Enzyme Linked Immunosorbent Assay.</p> Results <p>The expression of hsa_circ_0049356 and the level of SIRT6 were significantly decreased in SLE patients. Moreover, SLE patients exhibited increased miR-338-3p expression and higher levels of ERK, MAPK, and MEK-1 compared to healthy controls.</p> Conclusion <p>This study suggests that the release of sponge effect of hsa_circ_0049356 on miR-338-3p leads to an increase in miR-338-3p, which may contribute to the pathogenesis of SLE by modulating the ERK/MAPK pathway.</p>

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The possible role of hsa_circ_0049356 and hsa-miR-338-3p in systemic lupus erythematosus disease

  • 期刊论文

  • 发表日期：

    2025年7月3日

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  • Mai Samir,
  • Rana Mohamed Abd el-rahman,
  • Laila Rashed,
  • Mohamed Magdy,
  • Doaa M. Gharib

摘要

Background

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a variety of clinical manifestations and a relapsing–remitting course. MiR-338-3p has emerged as a significant regulator of the immune response in the pathogenesis of SLE. Hsa_circ_0049356 is a circular RNA that may serve as a potential biological or clinical marker for autoimmune disorders.

Purpose of the study

This study aims to evaluate the potential role of hsa_circ_0049356 and miR-338-3p in the pathogenesis of SLE by analyzing their expression patterns and assessing their impact on the ERK/MAPK signaling pathway. Understanding these interactions may provide novel insights into the pathogenesis of SLE and identify potential diagnostic or therapeutic targets.

Methods

This study included 100 participants, divided into two groups: healthy controls and SLE patients. Comprehensive clinical evaluations, including history taking, physical examination, and laboratory investigations, were performed. The expression levels of hsa_circ_0049356 and miR-338-3p were determined using RT-PCR. Additionally, the levels of SIRT6, ERK, MAPK, and MEK-1 were measured using Enzyme Linked Immunosorbent Assay.

Results

The expression of hsa_circ_0049356 and the level of SIRT6 were significantly decreased in SLE patients. Moreover, SLE patients exhibited increased miR-338-3p expression and higher levels of ERK, MAPK, and MEK-1 compared to healthy controls.

Conclusion

This study suggests that the release of sponge effect of hsa_circ_0049356 on miR-338-3p leads to an increase in miR-338-3p, which may contribute to the pathogenesis of SLE by modulating the ERK/MAPK pathway.