Scholarlink

Background <p>Diabetes Mellitus (DM) impairs male reproductive functions by modulating apoptosis, oxidation, and the inflammatory pathway. The studies were planned to screen the ability of the hydro-alcoholic extract (AN) prepared using the roots of <i>Argyreia nervosa</i> (<i>A. nervosa</i>) (Burm.Fil.) Bojer. (<i>Family: Convolvulaceae)</i> in alleviating the DM-induced detrimental functioning of male reproductive functions in experimental rats.</p> Method and results <p>Diabetic conditions were induced by the combined administration of a high-fat diet and a single injection of streptozotocin (30&#xa0;mg/kg). Diabetic rats treated with a higher dose of <i>A. nervosa</i> extract (ANH) showed decreased fasting blood glucose (0.52-fold), abnormal sperm morphology (0.50-fold), and sperm DNA fragmentation index (0.74-fold), along with improved semen quality. ANH increased testicular testosterone (1.40-fold), FSH (1.91-fold), LH (1.69-fold), and mRNA expression of StAR (1.75-fold), 17β-HSD (1.77-fold), and 3β-HSD (1.06-fold). It reduced MDA (0.72-fold) and raised SOD (1.93-fold) and GSH (2.13-fold). ANH also lowered mRNA/protein levels of RAGE (0.75-fold, 8.81-fold), TNF-α (0.79-fold, 2.11-fold), NLRP3 (0.68-fold, 8.15-fold), and Caspase-3 (0.87-fold, 8.45-fold).</p> Conclusion <p>AN, thus, showed the potential beneficial effects on DM-induced male infertility, probably through its ability to counter DM induced apoptosis and inflammation in testicular tissues along with supporting anti-oxidant mechanisms. The extract could upregulate testosterone biosynthesis by modulating steroidogenic enzyme activity and stimulating FSH and LH levels. This action further supported the improvement of sperm functioning parameters in diabetic rats. These results provided the potential of AN as an alternative treatment for the clinical management of DM-impaired male reproductive function, offering hope for future research and clinical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Argyreia nervosa (Brum.f.) Bojer. alleviates diabetes mellitus-induced male infertility

  • 期刊论文

  • 发表日期：

    2025年6月4日

查看全文
  • Pooja Veljibhai Gori,
  • Manan Raval,
  • Samir Patel,
  • Amit Patel,
  • Nilay Solanki,
  • Priyal Patel,
  • Manish Nandpal,
  • Palash Mandal,
  • Hiral Aghara

摘要

Background

Diabetes Mellitus (DM) impairs male reproductive functions by modulating apoptosis, oxidation, and the inflammatory pathway. The studies were planned to screen the ability of the hydro-alcoholic extract (AN) prepared using the roots of Argyreia nervosa (A. nervosa) (Burm.Fil.) Bojer. (Family: Convolvulaceae) in alleviating the DM-induced detrimental functioning of male reproductive functions in experimental rats.

Method and results

Diabetic conditions were induced by the combined administration of a high-fat diet and a single injection of streptozotocin (30 mg/kg). Diabetic rats treated with a higher dose of A. nervosa extract (ANH) showed decreased fasting blood glucose (0.52-fold), abnormal sperm morphology (0.50-fold), and sperm DNA fragmentation index (0.74-fold), along with improved semen quality. ANH increased testicular testosterone (1.40-fold), FSH (1.91-fold), LH (1.69-fold), and mRNA expression of StAR (1.75-fold), 17β-HSD (1.77-fold), and 3β-HSD (1.06-fold). It reduced MDA (0.72-fold) and raised SOD (1.93-fold) and GSH (2.13-fold). ANH also lowered mRNA/protein levels of RAGE (0.75-fold, 8.81-fold), TNF-α (0.79-fold, 2.11-fold), NLRP3 (0.68-fold, 8.15-fold), and Caspase-3 (0.87-fold, 8.45-fold).

Conclusion

AN, thus, showed the potential beneficial effects on DM-induced male infertility, probably through its ability to counter DM induced apoptosis and inflammation in testicular tissues along with supporting anti-oxidant mechanisms. The extract could upregulate testosterone biosynthesis by modulating steroidogenic enzyme activity and stimulating FSH and LH levels. This action further supported the improvement of sperm functioning parameters in diabetic rats. These results provided the potential of AN as an alternative treatment for the clinical management of DM-impaired male reproductive function, offering hope for future research and clinical applications.