<p>A heterogeneous nanocatalyst (Fe₃O₄@UiO-67-bpy-Cu) was rationally designed and synthesized, and applied to the production of imidazopyridine derivatives. The catalyst is based on an Fe₃O₄ core superparamagnetic and an efficient Zr-based UiO-67 framework, which is functionalized with 2,2′-bipyridine ligands to allow the catalytically active Cu centers to be stabilized in a porous form. Detailed characterization through the necessary analyses verified the successful production of the core–shell structure. It was found that this catalytic system allows the production of a large number of substituted imidazopyridines in excellent yields and is effective in driving the reaction at moderate temperatures. The combination of a strong binding affinity of Cu-bipyridine, high porosity, and magnetic recovery is an efficient and sustainable substitute for homogeneous copper, typical of conventional systems, and the extent of metal contamination is reduced, and the recovery of the catalyst is also simplified. Imidazopyridine scaffolds have long been known to possess pharmacological activity and have attracted increasing attention for their promising potential in agricultural chemistry applications, particularly as antifungal and insecticidal agents. Consequently, the consequent catalytic system is a convenient means towards rapid synthesis of structurally diverse heterocycles with potential implications in biomedical and agricultural chemistry.</p>