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<p>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive impairment. It seriously affects the health and quality of life of the elderly. It has a complex pathogenesis including β-amyloid (Aβ) deposition, Tau protein hyperphosphorylation, cholinergic neurotransmitter deficiency, metal ion dyshomeostasis, and oxidative stress, etc. Despite intensive research, there is still a lack of effective clinical drugs to treat or control AD progression. Natural products and their derivatives exhibit multi-target anti-AD effects, together with low toxicity and affordability, have emerged as promising lead compounds for drug discovery. This review summarizes the studies on anti-AD activities of natural products bearing γ-pyranone structure and their derivatives, and further discusses their structure–activity relationships (SARs), which provided a theoretical basis for the development of effective anti-AD drugs.</p>

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Study on the structure–activity relationships of natural γ-pyranone products and their derivatives with anti-AD activities focusing on metal chelation

  • 期刊论文

  • 发表日期：

    2025年12月3日

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  • Junyi Mao,
  • Caiyun Wang,
  • Xiangyu Li,
  • Ruihao Du,
  • Xiangyu Zhang,
  • Rui Shen,
  • Aihong Yang,
  • Xiaodi Kou

摘要

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive impairment. It seriously affects the health and quality of life of the elderly. It has a complex pathogenesis including β-amyloid (Aβ) deposition, Tau protein hyperphosphorylation, cholinergic neurotransmitter deficiency, metal ion dyshomeostasis, and oxidative stress, etc. Despite intensive research, there is still a lack of effective clinical drugs to treat or control AD progression. Natural products and their derivatives exhibit multi-target anti-AD effects, together with low toxicity and affordability, have emerged as promising lead compounds for drug discovery. This review summarizes the studies on anti-AD activities of natural products bearing γ-pyranone structure and their derivatives, and further discusses their structure–activity relationships (SARs), which provided a theoretical basis for the development of effective anti-AD drugs.