<p>The goal of this study was to analyze the deformation behavior of immobilizing ceramic ZrO₂ splints of two dimensions under static and cyclic operational loads to determine their endurance, taking into account the possible presence of microcracks. To address the problem, the minimum possible thickness of the ZrO₂ splint was determined with the use of computer simulation of its stress-strain states under static operational loads. The service life was predicted by simulating the fatigue behavior under cyclic loading at ‘typical’ operational (biting and mastication) loads. According to calculations, the splint thickness has to be justified by the most significant individual characteristics at both alveoli and periodontal ligament (PDL) degradations, as well as at the presence of cracks in its outer surface. For both ZrO₂ splints with the alveolar ridge height reductions, the ultimate fatigue loads decreased by 2-2.5 times regardless of the presence of cracks. Based on the results obtained, the most significant factors catastrophically affecting the fatigue life of the ‘thin’ and ‘thick’ ZrO₂ splints were identified: (i) the alveolar ridge height reduction above 2/3, and (ii) the presence of cracks longer than 100 μm in the stress concentration regions. It was shown that cracks at the contacts of the ZrO₂ splints and the teeth do not affect the fatigue durability.</p>