<p>In order to obtain the effects of different layup sequences on the properties and microstructures of graphene-carbon fiber/basalt fiber (GO-CF/BF) hybrid reinforced composite materials, six GO-CF/BF hybrid reinforced composites with different lay-up sequences were prepared using the vacuum infiltration hot press molding process (VIHPS) with carbon fibers that have excellent mechanical properties and basalt fibers as reinforcement. Then, they were characterized for micropatterns and tested for bending properties, respectively. The results showed that when the lay-up sequence was BBBCCC, the internal fibers of the material were tightly wrapped by the matrix solution, and the basalt fibers under pressure exhibit better toughness, which can better disperse the stress and was less likely to produce stress concentration. As a result, the flexural strength of the composite reaches its maximum value of 410.59 MPa. When the layup was BCBCBC, due to the alternating arrangement of carbon and basalt fibers, a certain pressure gradient was generated inside the material, causing both carbon and basalt fibers to be tightly wrapped by the matrix, with basically no defects such as holes. However, there is a significant modulus gap between the two, which makes it difficult for the interface to coordinate bonding ability during the loading process, leading to issues such as delamination and thus reducing its bending strength. At this point, the bending strength was 362.31 MPa, a decrease of 11.7%. Conversely, when the layup was CBBBCC, the flexural strength of the composite was lowest, (277.52 MPa) with a decrease of 32.4%. This is due to the uneven infiltration of the matrix within the material, which produces defects such as holes and cracks, thereby affecting the interfacial bonding ability between the fibers and the matrix.</p>