<p>Psychedelic medicine is a rapidly growing, billion-dollar industry poised to transform mental health care by incorporating spiritual experiences into clinical psychiatry. However, while the blending of psychiatry and mystical experience has long made this field unique, the blurred boundaries between science and spiritual practice have sparked increasing public debate. What does the entanglement of science and religion in psychedelic medicine reveal about the concerns, anxieties, and yearnings of our contemporary social and political moment? This article draws on an analysis of public discourse alongside ethnographic and qualitative research within a psychedelic church, a psychedelic-assisted therapy training program, and psychedelic science conferences in the United States. Through stories of the intertwining of science and religion, psychotherapy and mysticism, and attempts to distinguish between drugs, medicine, and sacraments in both clinical and non-clinical spaces, I argue that the mainstreaming of psychedelic medicine is not only shifting paradigms of mental health care but also creating new forms of secular mysticism in an age of disenchantment.</p>