Scholarlink

<p>Cadmium is a highly neurotoxic heavy metal that impacts the functions of several organs through stimulating excessive oxidative stress. Polyphenols were evidenced to mitigate heavy metal-induced neurotoxicity and pulmonary toxicity. Crocin (CN) is a carotenoid compound extracted from <i>Crocus sativus</i> L. This study explored the protective activities of CN against Cadmium chloride (CdCl<sub>2</sub>)-induced neurotoxicity and lung injury. Thirty-two female albino Wistar rats, 6–8 weeks-old, were allocated into four groups: Negative control, CdCl<sub>2</sub>-intoxicated rats (two successive intraperitoneal doses of 1 and 3&#xa0;mg/kg body weight), CN group, and treated CdCl<sub>2</sub> rats with CN (50&#xa0;mg/kg body weight, orally). Hanging-wire test was used to assess the muscular coordination. Biochemically, lipid peroxidation and glutathione (GSH) contents in the brain and lung homogenates, serum iron and phosphorus levels, serum Glucagon-like Peptide-1 (GLP-1) and spexin (SPX) levels were measured, along with histopathological investigation of cerebellar and pulmonary tissues. CdCl<sub>2</sub> rats demonstrated loss of neuromuscular coordination and imbalance in the hanging-wire test. Furthermore, CdCl<sub>2</sub> rats exhibited increased lipid peroxidation, GSH decline, disruption of iron and phosphorus levels, and reduction of GLP-1 and SPX levels. Concomitant treatment of CdCl<sub>2</sub>-rats with CN, for two weeks, restored the muscular strength, mitigated oxidative stress, regulated iron and phosphorus levels, modulated GLP-1 and SPX, and ameliorated the histopathological features in the cerebellum and the lungs. We concluded that CN exerted neuroprotective and pulmonary protective potentials against CdCl<sub>2</sub>-induced toxicity, and that GLP-1 and SPX could be regarded as biomarkers of heavy metals-associated neurotoxicity and lung toxicity.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Crocin alleviates “short-term” Cadmium-induced brain and lung toxicities: investigation of key neuropeptides GLP-1 and spexin as biomarkers

  • 期刊论文

  • 发表日期：

    2026年7月3日

查看全文
  • Ghadha Ibrahim Fouad

摘要

Cadmium is a highly neurotoxic heavy metal that impacts the functions of several organs through stimulating excessive oxidative stress. Polyphenols were evidenced to mitigate heavy metal-induced neurotoxicity and pulmonary toxicity. Crocin (CN) is a carotenoid compound extracted from Crocus sativus L. This study explored the protective activities of CN against Cadmium chloride (CdCl2)-induced neurotoxicity and lung injury. Thirty-two female albino Wistar rats, 6–8 weeks-old, were allocated into four groups: Negative control, CdCl2-intoxicated rats (two successive intraperitoneal doses of 1 and 3 mg/kg body weight), CN group, and treated CdCl2 rats with CN (50 mg/kg body weight, orally). Hanging-wire test was used to assess the muscular coordination. Biochemically, lipid peroxidation and glutathione (GSH) contents in the brain and lung homogenates, serum iron and phosphorus levels, serum Glucagon-like Peptide-1 (GLP-1) and spexin (SPX) levels were measured, along with histopathological investigation of cerebellar and pulmonary tissues. CdCl2 rats demonstrated loss of neuromuscular coordination and imbalance in the hanging-wire test. Furthermore, CdCl2 rats exhibited increased lipid peroxidation, GSH decline, disruption of iron and phosphorus levels, and reduction of GLP-1 and SPX levels. Concomitant treatment of CdCl2-rats with CN, for two weeks, restored the muscular strength, mitigated oxidative stress, regulated iron and phosphorus levels, modulated GLP-1 and SPX, and ameliorated the histopathological features in the cerebellum and the lungs. We concluded that CN exerted neuroprotective and pulmonary protective potentials against CdCl2-induced toxicity, and that GLP-1 and SPX could be regarded as biomarkers of heavy metals-associated neurotoxicity and lung toxicity.

Graphical abstract